N-(2-Methylamino-5-trifluoromethyl-phenyl)-phthalamic acid

Base Information

• Chemical Name: N-(2-Methylamino-5-trifluoromethyl-phenyl)-phthalamic acid
• CAS No.: 120914-47-8
• Molecular Formula: C₁₆H₁₃F₃N₂O₃
• Molecular Weight: 338.286
• Mol file: 120914-47-8.mol

Synonyms:N-(2-Methylamino-5-trifluoromethyl-phenyl)-phthalamic acid

Chemical Property of N-(2-Methylamino-5-trifluoromethyl-phenyl)-phthalamic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-Methylamino-5-trifluoromethyl-phenyl)-phthalamic acid

There total 1 articles about N-(2-Methylamino-5-trifluoromethyl-phenyl)-phthalamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

phthalic anhydride (85-44-9) + N1-methyl-4-(trifluoromethyl)benzene-1,2-diamine (35203-49-7) → N-(2-Methylamino-5-trifluoromethyl-phenyl)-phthalamic acid (120914-47-8)

Guidance literature:

In ethanol; for 2h; Heating;

Reference yield: 60.0%

ethanol (64-17-5) + N-(2-Methylamino-5-trifluoromethyl-phenyl)-phthalamic acid (120914-47-8) → ethyl 2-<1-methyl-5-(trifluoromethyl)benzimidazol-2-yl>benzoate (120914-48-9)

Guidance literature:

With sulfuric acid; for 3h; Heating;

Reference yield:

N-(2-Methylamino-5-trifluoromethyl-phenyl)-phthalamic acid (120914-47-8) → 2-<1-methyl-5-(trifluoromethyl)benzimidazol-2-yl>benzamide (120914-45-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 60 percent / conc. H₂SO₄ / 3 h / Heating

2: CH₂Cl₂ / 0.5 h / 0 °C

3: aq. K₂CO₃ / ethanol / 0.08 h

4: 60 percent / water / various solvent(s) / 10 h / Heating; without added water

With sulfuric acid; water; potassium carbonate; In ethanol; dichloromethane;

upstream raw materials:

phthalic anhydride

N¹-methyl-4-(trifluoromethyl)benzene-1,2-diamine

Downstream raw materials:

ethyl 2-<1-methyl-5-(trifluoromethyl)benzimidazol-2-yl>benzoate

2-<1-methyl-5-(trifluoromethyl)benzimidazol-2-yl>benzamide

2,4,6-Trimethyl-benzenesulfonate1-amino-2-(2-ethoxycarbonyl-phenyl)-3-methyl-6-trifluoromethyl-3H-benzoimidazol-1-ium;