[2-(4-amino-2,6-dichlorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

Base Information

Chemical Name:[2-(4-amino-2,6-dichlorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine
CAS No.:1378038-53-9
Molecular Formula:C₁₇H₁₂Cl₂FN₇
Molecular Weight:404.234
Hs Code.:

Synonyms:[2-(4-amino-2,6-dichlorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

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Chemical Property of [2-(4-amino-2,6-dichlorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

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Technology Process of [2-(4-amino-2,6-dichlorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

There total 9 articles about [2-(4-amino-2,6-dichlorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1378040-34-6
[2-(2,6-dichloro-4-nitrophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

: 1378038-53-9
[2-(4-amino-2,6-dichlorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

Guidance literature:: With iron; ammonium chloride; In tetrahydrofuran; ethanol; water; at 70 ℃; for 9h;

Reference yield:

: 2546-56-7
4-chloro-3-fluoro-pyridine

: 1378038-53-9
[2-(4-amino-2,6-dichlorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

Guidance literature:: Multi-step reaction with 9 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 18.75 h / -78 - -30 °C

1.2: 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

3.1: triethylamine; titanium tetrachloride / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4.1: toluene / 4 h / 105 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6.25 h / 0 - 20 °C

6.1: trichlorophosphate / 1,2-dichloro-ethane / 1.58 h / 70 °C / Inert atmosphere

7.1: trimethylsilyl bromide / propiononitrile / 105 °C / Inert atmosphere

8.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

9.1: ammonium chloride; iron / ethanol; water; tetrahydrofuran / 9 h / 70 °C

With n-butyllithium; sodium azide; trimethylsilyl bromide; titanium tetrachloride; iron; ammonium chloride; caesium carbonate; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; hexane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; propiononitrile;

Reference yield:

: 1060802-34-7
4-chloro-5-fluoropyridine-3-carboxaldehyde

: 1378038-53-9
[2-(4-amino-2,6-dichlorophenyl)-7-fluoro-2H-pyrazolo[4,3-c]pyridin-4-yl]-(6-methylpyrimidin-4-yl)-amine

Guidance literature:: Multi-step reaction with 8 steps

1: sodium azide / N,N-dimethyl-formamide / 18 h / 20 °C

2: triethylamine; titanium tetrachloride / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

3: toluene / 4 h / 105 °C

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6.25 h / 0 - 20 °C

5: trichlorophosphate / 1,2-dichloro-ethane / 1.58 h / 70 °C / Inert atmosphere

6: trimethylsilyl bromide / propiononitrile / 105 °C / Inert atmosphere

7: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

8: ammonium chloride; iron / ethanol; water; tetrahydrofuran / 9 h / 70 °C

With sodium azide; trimethylsilyl bromide; titanium tetrachloride; iron; ammonium chloride; caesium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; propiononitrile;