(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-(fluoromethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

Base Information

Chemical Name:(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-(fluoromethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane
CAS No.:884381-91-3
Molecular Formula:C₁₆H₁₈ClFN₂O₂
Molecular Weight:324.783
Hs Code.:

Synonyms:(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-(fluoromethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

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Chemical Property of (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-(fluoromethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

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Technology Process of (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-(fluoromethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

There total 3 articles about (2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-(fluoromethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143327-63-3
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-[(p-toluenesulfonyloxy)methyl]-1,3-dioxalane

: 884381-91-3
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-(fluoromethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 18.5h; Reflux;
DOI:10.1016/j.bmc.2009.01.078

Reference yield:

: 82362-50-3
4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanone

: 884381-91-3
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-(fluoromethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene; butan-1-ol / 8 h / Heating / reflux

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 18.5 h / Heating / reflux

With tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran; toluene; butan-1-ol;

Reference yield:

: 67085-11-4
1-[2-hydroxy-4-(4-chlorophenyl)-n-butyl]imidazole

: 884381-91-3
(2R,4S)-2-[2-(4-chlorophenyl)ethyl]-4-(fluoromethyl)-2-[(1H-imidazol-1-yl)methyl]-1,3-dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; dimethyl sulfoxide; triethylamine

2: toluene-4-sulfonic acid / toluene; butan-1-ol / 8 h / Heating / reflux

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 18.5 h / Heating / reflux

With oxalyl dichloride; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; toluene; butan-1-ol; 1: Swern Oxidation;