(R)-1-[1-(2-cyanobenzyl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl]piperidin-3-yl tert-butyl carbamate

Base Information

Chemical Name:(R)-1-[1-(2-cyanobenzyl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl]piperidin-3-yl tert-butyl carbamate
CAS No.:1314946-32-1
Molecular Formula:C₂₆H₃₂N₆O₃
Molecular Weight:476.578
Hs Code.:

Synonyms:(R)-1-[1-(2-cyanobenzyl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl]piperidin-3-yl tert-butyl carbamate

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Chemical Property of (R)-1-[1-(2-cyanobenzyl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl]piperidin-3-yl tert-butyl carbamate

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Technology Process of (R)-1-[1-(2-cyanobenzyl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl]piperidin-3-yl tert-butyl carbamate

There total 3 articles about (R)-1-[1-(2-cyanobenzyl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl]piperidin-3-yl tert-butyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1314946-30-9
(R)-1-(3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)piperidin-3-yl tert-butyl carbamate

: 22115-41-9
2-(bromomethyl)benzonitrile

: 1314946-32-1
(R)-1-[1-(2-cyanobenzyl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl]piperidin-3-yl tert-butyl carbamate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at -10 ℃; Inert atmosphere;
DOI:10.1021/ml5001905

Reference yield: 70.5%

: 1314946-32-1
(R)-1-[1-(2-cyanobenzyl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl]piperidin-3-yl tert-butyl carbamate

Guidance literature:

Reference yield:

: 63897-12-1
2,4-dichloro-6-methyl-3-nitropyridine

: 1314946-32-1
(R)-1-[1-(2-cyanobenzyl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl]piperidin-3-yl tert-butyl carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / ethanol / 2 h / 20 °C / Inert atmosphere

2: ethanol; butan-1-ol / 24 h / 110 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 3 h / Inert atmosphere

4: triethylamine / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / -10 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/ml5001905