(R)-2-[[7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile trifluoroacetate

Base Information

Chemical Name:(R)-2-[[7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile trifluoroacetate
CAS No.:1314944-08-5
Molecular Formula:C₂HF₃O₂*C₂₁H₂₄N₆O
Molecular Weight:490.485
Hs Code.:

Synonyms:(R)-2-[[7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile trifluoroacetate

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Chemical Property of (R)-2-[[7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile trifluoroacetate

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Technology Process of (R)-2-[[7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile trifluoroacetate

There total 5 articles about (R)-2-[[7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

: 1314944-08-5
(R)-2-[[7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile trifluoroacetate

Guidance literature:

Reference yield: 88.0%

: 1314946-32-1
(R)-1-[1-(2-cyanobenzyl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b] pyridin-7-yl]piperidin-3-yl tert-butyl carbamate

: 76-05-1
trifluoroacetic acid

: 1314944-08-5
(R)-2-[[7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile trifluoroacetate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ml5001905

Reference yield:

: 4966-90-9
4-hydroxy-6-methyl-3-nitro-2(1H)-pyridinone

: 1314944-08-5
(R)-2-[[7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: trichlorophosphate; N,N-dimethyl-aniline / 1.5 h / 95 °C / Inert atmosphere

2: triethylamine / ethanol / 2 h / 20 °C / Inert atmosphere

3: ethanol; butan-1-ol / 24 h / 110 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 3 h / Inert atmosphere

5: triethylamine / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

6: potassium carbonate / N,N-dimethyl-formamide / -10 °C / Inert atmosphere

7: dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/ml5001905