tert-butyl 3-(3-(5-methyl-4-(3-nitrophenylamino)pyrimidin-2-ylamino)phenoxy)propylcarbamate

Base Information

Chemical Name:tert-butyl 3-(3-(5-methyl-4-(3-nitrophenylamino)pyrimidin-2-ylamino)phenoxy)propylcarbamate
CAS No.:1202760-18-6
Molecular Formula:C₂₅H₃₀N₆O₅
Molecular Weight:494.55
Hs Code.:

Synonyms:tert-butyl 3-(3-(5-methyl-4-(3-nitrophenylamino)pyrimidin-2-ylamino)phenoxy)propylcarbamate

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Chemical Property of tert-butyl 3-(3-(5-methyl-4-(3-nitrophenylamino)pyrimidin-2-ylamino)phenoxy)propylcarbamate

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Technology Process of tert-butyl 3-(3-(5-methyl-4-(3-nitrophenylamino)pyrimidin-2-ylamino)phenoxy)propylcarbamate

There total 7 articles about tert-butyl 3-(3-(5-methyl-4-(3-nitrophenylamino)pyrimidin-2-ylamino)phenoxy)propylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1202759-74-7
2-chloro-5-methyl-N⁴-[3-nitrophenyl]pyrimidine4-amine

: 1175649-60-1
[3-(3-aminophenoxy)propyl]carbamic acid tert-butyl ester

: 1202760-18-6
tert-butyl 3-(3-(5-methyl-4-(3-nitrophenylamino)pyrimidin-2-ylamino)phenoxy)propylcarbamate

Guidance literature:: With acetic acid; In ethanol; at 90 ℃; for 16h; Sealed tube;
DOI:10.1124/jpet.113.203489

Reference yield:

: 58885-58-8
N-tert-butoxycarbonyl-3-aminopropanol

: 1202760-18-6
tert-butyl 3-(3-(5-methyl-4-(3-nitrophenylamino)pyrimidin-2-ylamino)phenoxy)propylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

3: hydrogen; palladium 10% on activated carbon / ethanol / 16 h / 20 °C

4: acetic acid / ethanol / 16 h / 90 °C / Sealed tube

With palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1124/jpet.113.203489

Reference yield:

: 112663-43-1
3-(tert-butoxycarbonylamino)propyl methanesulfonate

: 1202760-18-6
tert-butyl 3-(3-(5-methyl-4-(3-nitrophenylamino)pyrimidin-2-ylamino)phenoxy)propylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 60 °C

2: hydrogen; palladium 10% on activated carbon / ethanol / 16 h / 20 °C

3: acetic acid / ethanol / 16 h / 90 °C / Sealed tube

With palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In ethanol; N,N-dimethyl-formamide;
DOI:10.1124/jpet.113.203489