tert-butyl (4-aminophenyl)(4-((tert-butoxycarbonyl)(4-((tertbutoxycarbonyl)(phenyl)amino)phenyl)amino)phenyl)carbamate

Base Information

• Chemical Name: tert-butyl (4-aminophenyl)(4-((tert-butoxycarbonyl)(4-((tertbutoxycarbonyl)(phenyl)amino)phenyl)amino)phenyl)carbamate
• CAS No.: 535960-12-4
• Molecular Formula: C₃₉H₄₆N₄O₆
• Molecular Weight: 666.817
• Mol file: 535960-12-4.mol

Synonyms:tert-butyl (4-aminophenyl)(4-((tert-butoxycarbonyl)(4-((tertbutoxycarbonyl)(phenyl)amino)phenyl)amino)phenyl)carbamate

Chemical Property of tert-butyl (4-aminophenyl)(4-((tert-butoxycarbonyl)(4-((tertbutoxycarbonyl)(phenyl)amino)phenyl)amino)phenyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (4-aminophenyl)(4-((tert-butoxycarbonyl)(4-((tertbutoxycarbonyl)(phenyl)amino)phenyl)amino)phenyl)carbamate

There total 3 articles about tert-butyl (4-aminophenyl)(4-((tert-butoxycarbonyl)(4-((tertbutoxycarbonyl)(phenyl)amino)phenyl)amino)phenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (4-((tert-butoxycarbonyl)(4-((tert-butoxycarbonyl)(4-((diphenylmethylene)amino)phenyl)amino)phenyl)amino)phenyl)(phenyl)carbamate (535960-11-3) → tert-butyl (4-aminophenyl)(4-((tert-butoxycarbonyl)(4-((tertbutoxycarbonyl)(phenyl)amino)phenyl)amino)phenyl)carbamate (535960-12-4)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In tetrahydrofuran; methanol; for 24h; Heating;

DOI:10.1021/ma030033+

Reference yield:

- → tert-butyl (4-aminophenyl)(4-((tert-butoxycarbonyl)(4-((tertbutoxycarbonyl)(phenyl)amino)phenyl)amino)phenyl)carbamate (535960-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-(dimethylamino)pyridine / tetrahydrofuran / 24 h / Heating

2: ammonium formate / Pd/C / methanol; tetrahydrofuran / 24 h / Heating

With dmap; ammonium formate; palladium on activated charcoal; In tetrahydrofuran; methanol;

DOI:10.1021/ma030033+

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (4-aminophenyl)(4-((tert-butoxycarbonyl)(4-((tertbutoxycarbonyl)(phenyl)amino)phenyl)amino)phenyl)carbamate (535960-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / tetrahydrofuran / 72 h / Inert atmosphere; Schlenk technique; Reflux

2: ammonium formate; palladium 10% on activated carbon / tetrahydrofuran; methanol / 24 h / Inert atmosphere; Reflux

With dmap; palladium 10% on activated carbon; ammonium formate; In tetrahydrofuran; methanol;

DOI:10.1021/jacs.5b06892

upstream raw materials:

tert-butyl (4-((tert-butoxycarbonyl)(4-((tert-butoxycarbonyl)(4-((diphenylmethylene)amino)phenyl)amino)phenyl)amino)phenyl)(phenyl)carbamate

di-tert-butyl dicarbonate

Downstream raw materials:

C₆₅H₆₇N₇O₈

(4-{tert-butoxycarbonyl-[4-(tert-butoxycarbonyl-phenyl-amino)-phenyl]-amino}-phenyl)-[4-(2-methyl-acryloylamino)-phenyl]-carbamic acid tert-butyl ester