3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-4-cyclohexylbutane nitrile

Base Information

Chemical Name:3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-4-cyclohexylbutane nitrile
CAS No.:1269823-37-1
Molecular Formula:C₁₉H₂₂N₆
Molecular Weight:334.424
Hs Code.:

Synonyms:3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-4-cyclohexylbutane nitrile

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Chemical Property of 3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-4-cyclohexylbutane nitrile

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Technology Process of 3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-4-cyclohexylbutane nitrile

There total 14 articles about 3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-4-cyclohexylbutane nitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1269823-38-2
(4-(1-(1-cyano-3-cyclohexylpropan-2-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-c]pyridazin-7-yl)methyl pivalate

: 1269823-37-1
3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-4-cyclohexylbutane nitrile

Guidance literature:: With sodium hydroxide; In methanol; at 20 ℃; for 3h;

Reference yield:

: 1269822-93-6
1-(4-acetyl-5-nitro-1H-pyrrol-2-yl)-2,2,2-trichloroethanone

: 1269823-37-1
3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-4-cyclohexylbutane nitrile

Guidance literature:: Multi-step reaction with 11 steps

1.1: methanol / 0.5 h / 20 °C

1.2: 20 °C

2.1: acetic acid; iron / 0.5 h / 45 - 100 °C

3.1: sodium nitrite / water; acetic acid / 48 h / 18 - 65 °C

4.1: potassium hydroxide / 0.5 h / 70 °C

4.2: 20 °C

5.1: trifluoroacetic acid / 48 h / 230 °C / Sealed ampoule

6.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-aniline / acetonitrile / 2 h / 80 °C

7.1: dmap; triethylamine / dichloromethane / -10 - 50 °C

8.1: potassium carbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

9.1: hydrogenchloride / water; tetrahydrofuran / 10 h / 20 °C

10.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C

11.1: sodium hydroxide / methanol / 3 h / 20 °C

With hydrogenchloride; dmap; N-benzyl-N,N,N-triethylammonium chloride; water; iron; potassium carbonate; acetic acid; N,N-dimethyl-aniline; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; sodium nitrite; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid; acetonitrile;

Reference yield:

: 1269822-94-7
methyl 4-acetyl-5-nitro-1H-pyrrole-2-carboxylate

: 1269823-37-1
3-(4-(7H-pyrrolo[2,3-c]pyridazin-4-yl)-1H-pyrazol-1-yl)-4-cyclohexylbutane nitrile

Guidance literature:: Multi-step reaction with 10 steps

1.1: acetic acid; iron / 0.5 h / 45 - 100 °C

2.1: sodium nitrite / water; acetic acid / 48 h / 18 - 65 °C

3.1: potassium hydroxide / 0.5 h / 70 °C

3.2: 20 °C

4.1: trifluoroacetic acid / 48 h / 230 °C / Sealed ampoule

5.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride; N,N-dimethyl-aniline / acetonitrile / 2 h / 80 °C

6.1: dmap; triethylamine / dichloromethane / -10 - 50 °C

7.1: potassium carbonate; water / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

8.1: hydrogenchloride / water; tetrahydrofuran / 10 h / 20 °C

9.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C

10.1: sodium hydroxide / methanol / 3 h / 20 °C

With hydrogenchloride; dmap; N-benzyl-N,N,N-triethylammonium chloride; water; iron; potassium carbonate; acetic acid; N,N-dimethyl-aniline; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium hydroxide; sodium nitrite; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid; acetonitrile;