benzyl 3-(2-acetoxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate

Base Information

• Chemical Name: benzyl 3-(2-acetoxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate
• CAS No.: 925685-09-2
• Molecular Formula: C₂₇H₃₈O₉P₂
• Molecular Weight: 568.541
• Mol file: 925685-09-2.mol

Synonyms:benzyl 3-(2-acetoxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate

Chemical Property of benzyl 3-(2-acetoxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 3-(2-acetoxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate

There total 7 articles about benzyl 3-(2-acetoxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

benzyl 3-(2-hydroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate (925685-08-1) + acetyl chloride (75-36-5) → benzyl 3-(2-acetoxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate (925685-09-2)

Guidance literature:

With pyridine; dmap; for 2h; Inert atmosphere; Cooling with ice;

DOI:10.1021/jm801007z

Reference yield:

4,4-dimethyl-6-bromo-2-oxo-chroman (164012-31-1) → benzyl 3-(2-acetoxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate (925685-09-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 18 h / 100 °C

2.1: potassium hydroxide / methanol / 2 h / 20 °C

2.2: pH 4

3.1: potassium hydroxide / water; acetonitrile / 0.17 h

4.1: potassium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C

5.1: pyridine / dmap / 2 h / 0 °C

With pyridine; potassium hydroxide; triethylamine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

6-(ethoxy(diethylphosphonomethyl)phosphinoyl)-3,4-dihydro-4,4-dimethylchromen-2-one (925685-06-9) → benzyl 3-(2-acetoxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate (925685-09-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / methanol / 2 h / 20 °C

1.2: pH 4

2.1: potassium hydroxide / water; acetonitrile / 0.17 h

3.1: potassium hydroxide / N,N-dimethyl-formamide / 2 h / 20 °C

4.1: pyridine / dmap / 2 h / 0 °C

With pyridine; potassium hydroxide; dmap; In methanol; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

benzyl 3-(2-hydroxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoate

acetyl chloride

4,4-dimethyl-6-bromo-2-oxo-chroman

6-(ethoxy(diethylphosphonomethyl)phosphinoyl)-3,4-dihydro-4,4-dimethylchromen-2-one

Downstream raw materials:

3-(2-acetoxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoic acid

7-(4-(3-(2-acetoxy-5-(ethoxy(diethylphosphonomethyl)phosphinoyl)phenyl)-3-methylbutanoyl)-3-methylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid

7-(4-(3-(2-acetoxy-5-((phosphonomethyl)phosphonoyl)phenyl)-3-methylbutanoyl)-3-methylpiperazin-1-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid