4-chloro-1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-((5-(6-fluoro-3-pyridyl)-2-thienyl)methyl)benzene

Base Information

Chemical Name:4-chloro-1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-((5-(6-fluoro-3-pyridyl)-2-thienyl)methyl)benzene
CAS No.:842134-46-7
Molecular Formula:C₃₀H₂₉ClFNO₉S
Molecular Weight:634.079
Hs Code.:

Synonyms:4-chloro-1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-((5-(6-fluoro-3-pyridyl)-2-thienyl)methyl)benzene

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Chemical Property of 4-chloro-1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-((5-(6-fluoro-3-pyridyl)-2-thienyl)methyl)benzene

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Technology Process of 4-chloro-1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-((5-(6-fluoro-3-pyridyl)-2-thienyl)methyl)benzene

There total 12 articles about 4-chloro-1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-((5-(6-fluoro-3-pyridyl)-2-thienyl)methyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 842153-79-1
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-bromothiophen-2-yl)methyl)-4-chlorophenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 444120-95-0
2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

: 842134-46-7
4-chloro-1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-((5-(6-fluoro-3-pyridyl)-2-thienyl)methyl)benzene

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; cesium fluoride; In 1,2-dimethoxyethane; for 3h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2013.05.048

Reference yield:

: 842134-47-8
4-chloro-3-((5-(6-fluoro-3-pyridyl)-2-thienyl)methyl)-1-(β-D-glucopyranosyl)benzene

: 108-24-7
acetic anhydride

: 842134-46-7
4-chloro-1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-((5-(6-fluoro-3-pyridyl)-2-thienyl)methyl)benzene

Guidance literature:: With 4-methyl-morpholine; dmap; In tetrahydrofuran; at -10 - 20 ℃; for 1.5h; Product distribution / selectivity;

Reference yield:

: 842153-79-1
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(3-((5-bromothiophen-2-yl)methyl)-4-chlorophenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate

: 351019-18-6
(6-fluoropyridin-3-yl)boronic acid

: 842134-46-7
4-chloro-1-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-3-((5-(6-fluoro-3-pyridyl)-2-thienyl)methyl)benzene

Guidance literature:: With cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; for 1.5h; Product distribution / selectivity; Heating / reflux;