2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Base Information

Chemical Name:2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No.:444120-95-0
Molecular Formula:C11H15BFNO2
Molecular Weight:223.055
Hs Code.:2934999090
European Community (EC) Number:626-822-5
DSSTox Substance ID:DTXSID20479299
Wikidata:Q72476734
Mol file:444120-95-0.mol

Synonyms:444120-95-0;2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-Fluoropyridine-5-boronic acid pinacol ester;6-Fluoropyridine-3-boronic acid, pinacol ester;6-FLUOROPYRIDINE-3-BORONIC ACID PINACOL ESTER;2-fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-Flouropyridine-5-boronic acid pinacol ester;MFCD03412792;(6-FLUOROPYRIDIN-3-YL)BORONIC ACID PINACOL ESTER;Pyridine, 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;SCHEMBL484154;DTXSID20479299;ZKSRQMCKFLGPQU-UHFFFAOYSA-N;AKOS016011501;CS-W013102;HY-W012386;PB14350;DS-13640;SY024947;AM20051186;F1094;FT-0766369;A25322;ADENOSINE-8(3)H3,5-CYCLICMONOPHOSPHATE;EN300-318544;2-Fluoropyridine-5-boronic acid pinacol ester, >=95%;2-FLUORO-5-(4 4 5 5-TETRAMETHYL-(1 3 2)&;2-(6-Fluoro-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-Fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-pyridine;2-Fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)pyridine;2-Fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine;2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Suppliers and Price of 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Abosyn
2-Fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine >95%
5g
$ 49.00

Abosyn
2-Fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine >95%
10g
$ 70.00

AK Scientific
6-Fluoropyridine-3-boronicacidpinacolester
1g
$ 14.00

Alichem
2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
100g
$ 318.50

Ambeed
2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 97%
500g
$ 899.00

Ambeed
2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 97%
100g
$ 185.00

Ambeed
2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 97%
250mg
$ 6.00

TRC
6-Fluoropyridine-3-boronicacid,pinacolester
1g
$ 75.00

TCI Chemical
2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(GC)(T)
5g
$ 324.00

TCI Chemical
2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine >98.0%(GC)(T)
1g
$ 93.00

Total 51 raw suppliers

Chemical Property of 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Chemical Property:

Vapor Pressure:0.002mmHg at 25°C
Melting Point:29-33oC(lit.)
Boiling Point:304.208oC at 760 mmHg
PKA:-0.44±0.12(Predicted)
Flash Point:>230 °F
PSA：31.35000
Density:1.1g/cm3
LogP:1.51990
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:223.1179870
Heavy Atom Count:16
Complexity:257

Purity/Quality:

99%, ^*data from raw suppliers

2-Fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine >95% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:B1(OC(C(O1)(C)C)(C)C)C2=CN=C(C=C2)F

Technology Process of 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

There total 2 articles about 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 372-48-5
2-fluoropyridine

: 73183-34-3
bis(pinacol)diborane

: C₁₇H₂₆B₂FNO₄

: C₁₇H₂₆B₂FNO₄

: 452972-14-4
2-[3-(2-fluoro)pyridine]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 458532-86-0
2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine

: 444120-95-0
2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Guidance literature:: With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In tert-butyl methyl ether; at 20 ℃; for 24h; regioselective reaction; Glovebox; Sealed tube;
DOI:10.1039/c4ob01565g

Reference yield:

: 372-48-5
2-fluoropyridine

: 73183-34-3
bis(pinacol)diborane

: 452972-14-4
2-[3-(2-fluoro)pyridine]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 458532-86-0
2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine

: 444120-95-0
2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Guidance literature:: With n-butyllithium; C₂₈H₄₁ClNPPtSi; In hexane; 1,3,5-trimethyl-benzene; at 20 - 150 ℃; for 4h; Overall yield = 86 %; Overall yield = 77.4 mg; regioselective reaction; Inert atmosphere;
DOI:10.1039/c5cc07263h