3-[3-(2-Carboxy-ethyl)-4-((E)-6-p-tolyl-hex-5-enyloxy)-benzoyl]-benzoic acid

Base Information

Chemical Name:3-[3-(2-Carboxy-ethyl)-4-((E)-6-p-tolyl-hex-5-enyloxy)-benzoyl]-benzoic acid
CAS No.:128599-35-9
Molecular Formula:C₃₀H₃₀O₆
Molecular Weight:486.565
Hs Code.:

Synonyms:3-[3-(2-Carboxy-ethyl)-4-((E)-6-p-tolyl-hex-5-enyloxy)-benzoyl]-benzoic acid

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Chemical Property of 3-[3-(2-Carboxy-ethyl)-4-((E)-6-p-tolyl-hex-5-enyloxy)-benzoyl]-benzoic acid

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Technology Process of 3-[3-(2-Carboxy-ethyl)-4-((E)-6-p-tolyl-hex-5-enyloxy)-benzoyl]-benzoic acid

There total 10 articles about 3-[3-(2-Carboxy-ethyl)-4-((E)-6-p-tolyl-hex-5-enyloxy)-benzoyl]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 128577-89-9
3-[3-(2-Ethoxycarbonyl-ethyl)-4-((E)-6-p-tolyl-hex-5-enyloxy)-benzoyl]-benzoic acid ethyl ester

: 128599-35-9
3-[3-(2-Carboxy-ethyl)-4-((E)-6-p-tolyl-hex-5-enyloxy)-benzoyl]-benzoic acid

Guidance literature:: With potassium hydroxide; In ethanol; at 25 ℃; for 1h;
DOI:10.1021/jm00172a020

Reference yield:

: 128577-66-2
(E)-6-(p-tolyl)hex-5-en-1-ol

: 128599-35-9
3-[3-(2-Carboxy-ethyl)-4-((E)-6-p-tolyl-hex-5-enyloxy)-benzoyl]-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine (TEA) / diethyl ether

2: 1.) 60percent sodium hydride disp. in oil / 1.) DMF, 25 deg C, 30 min, 2.) 65 deg C

3: 57 percent / KOH / aq. ethanol / 1 h / 25 °C

With potassium hydroxide; sodium hydride; triethylamine; In diethyl ether; ethanol;
DOI:10.1021/jm00172a020

Reference yield:

: 67326-20-9
3-carbethoxybenzoyl chloride

: 128599-35-9
3-[3-(2-Carboxy-ethyl)-4-((E)-6-p-tolyl-hex-5-enyloxy)-benzoyl]-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) AlCl₃ / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) 0 deg C, 4 h

2: 92 percent / pyridine hydrochloride / 4 h / 180 °C

3: 56 percent / sulfuric acid / 96 h / Heating

4: 1.) 60percent sodium hydride disp. in oil / 1.) DMF, 25 deg C, 30 min, 2.) 65 deg C

5: 57 percent / KOH / aq. ethanol / 1 h / 25 °C

With potassium hydroxide; aluminium trichloride; sulfuric acid; pyridine hydrochloride; sodium hydride; In ethanol;
DOI:10.1021/jm00172a020