Technology Process of (2R,3R,5R)-1-benzoyloxy-5,6-isopropylidenedioxy-2-methyl-2,3-hexanediol
There total 6 articles about (2R,3R,5R)-1-benzoyloxy-5,6-isopropylidenedioxy-2-methyl-2,3-hexanediol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
methanesulfonamide; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine;
potassium dioxotetrahydroxoosmate(VI); potassium hexacyanoferrate(III);
In
tert-butyl alcohol;
for 2h;
ice-cooling;
DOI:10.1021/ja030133v
- Guidance literature:
-
Multi-step reaction with 5 steps
1: oxalyl chloride; DMSO; NEt3 / CH2Cl2 / -78 - 20 °C
2: 2.56 g / CH2Cl2 / 1 h / 20 °C
3: LiAlH4 / diethyl ether / 2 h / ice-cooling
4: 2.66 g / triethylamine / CH2Cl2 / 2 h / ice-cooling
5: aq. (DHQ)2PHAL; methanesulfonamide; K2CO3 / K2OsO2(OH)4; K3Fe(CN)6 / 2-methyl-propan-2-ol / 2 h / 0 °C
With
lithium aluminium tetrahydride; Hydroquinone 1,4-phthalazinediyl diether; oxalyl dichloride; methanesulfonamide; potassium carbonate; dimethyl sulfoxide; triethylamine;
potassium dioxotetrahydroxoosmate(VI); potassium hexacyanoferrate(III);
In
diethyl ether; dichloromethane; tert-butyl alcohol;
1: Swern oxidation;
DOI:10.1021/ja030133v
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 2.56 g / CH2Cl2 / 1 h / 20 °C
2: LiAlH4 / diethyl ether / 2 h / ice-cooling
3: 2.66 g / triethylamine / CH2Cl2 / 2 h / ice-cooling
4: aq. (DHQ)2PHAL; methanesulfonamide; K2CO3 / K2OsO2(OH)4; K3Fe(CN)6 / 2-methyl-propan-2-ol / 2 h / 0 °C
With
lithium aluminium tetrahydride; Hydroquinone 1,4-phthalazinediyl diether; methanesulfonamide; potassium carbonate; triethylamine;
potassium dioxotetrahydroxoosmate(VI); potassium hexacyanoferrate(III);
In
diethyl ether; dichloromethane; tert-butyl alcohol;
DOI:10.1021/ja030133v