C₂₉H₃₇N₇O₇

Base Information

• Chemical Name: C₂₉H₃₇N₇O₇
• CAS No.: 198622-42-3
• Molecular Formula: C₂₉H₃₇N₇O₇
• Molecular Weight: 595.655
• Mol file: 198622-42-3.mol

Synonyms:C₂₉H₃₇N₇O₇

Chemical Property of C₂₉H₃₇N₇O₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₃₇N₇O₇

There total 6 articles about C₂₉H₃₇N₇O₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

((S)-3-Benzyl-3-benzyloxycarbonylamino-2-oxo-pyrrolidin-1-yl)-acetic acid + C10H25N7O2*ClH → C29H37N7O7 (198622-42-3)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In acetonitrile; Ambient temperature;

DOI:10.1016/S0960-894X(97)00446-0

Reference yield:

Cbz-D-Phe (2448-45-5) → C29H37N7O7 (198622-42-3)

Guidance literature:

Multi-step reaction with 6 steps

2: 1) O₃, 2) PPh₃ / 1) CH₂Cl₂, -78 deg C, 2) -78 deg C -> room temperature

3: Et₃N, Na(OAc)3BH / 1,2-dichloro-ethane / 8 h / 0 - 20 °C

4: 1,2-dichloro-ethane / 10 h / Heating

5: 94 percent / TFA / CH₂Cl₂ / 0 - 20 °C

6: 45 percent / EDC, HOBt, DIPEA / acetonitrile / Ambient temperature

With sodium tris(acetoxy)borohydride; benzotriazol-1-ol; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1016/S0960-894X(97)00446-0

Reference yield:

(R)-2-Benzyl-2-benzyloxycarbonylamino-pent-4-enoic acid methyl ester (198622-39-8) → C29H37N7O7 (198622-42-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 1) O₃, 2) PPh₃ / 1) CH₂Cl₂, -78 deg C, 2) -78 deg C -> room temperature

2: Et₃N, Na(OAc)3BH / 1,2-dichloro-ethane / 8 h / 0 - 20 °C

3: 1,2-dichloro-ethane / 10 h / Heating

4: 94 percent / TFA / CH₂Cl₂ / 0 - 20 °C

5: 45 percent / EDC, HOBt, DIPEA / acetonitrile / Ambient temperature

With sodium tris(acetoxy)borohydride; benzotriazol-1-ol; ozone; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1016/S0960-894X(97)00446-0

upstream raw materials:

Cbz-D-Phe

(R)-2-Benzyl-2-benzyloxycarbonylamino-pent-4-enoic acid methyl ester

((S)-3-Benzyl-3-benzyloxycarbonylamino-2-oxo-pyrrolidin-1-yl)-acetic acid tert-butyl ester

(S)-2-Benzyl-2-benzyloxycarbonylamino-4-(tert-butoxycarbonylmethyl-amino)-butyric acid methyl ester