3'-O-(3-hydroxy-1,1,3,3-tetraisopropyldisiloxan-1-yl)-5'-O-(monomethoxytrityl)-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

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Chemical Name:3'-O-(3-hydroxy-1,1,3,3-tetraisopropyldisiloxan-1-yl)-5'-O-(monomethoxytrityl)-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine
CAS No.:173169-28-3
Molecular Formula:C₄₉H₆₃N₃O₁₃SSi₂
Molecular Weight:990.289
Hs Code.:

Synonyms:3'-O-(3-hydroxy-1,1,3,3-tetraisopropyldisiloxan-1-yl)-5'-O-(monomethoxytrityl)-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

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Chemical Property of 3'-O-(3-hydroxy-1,1,3,3-tetraisopropyldisiloxan-1-yl)-5'-O-(monomethoxytrityl)-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

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Technology Process of 3'-O-(3-hydroxy-1,1,3,3-tetraisopropyldisiloxan-1-yl)-5'-O-(monomethoxytrityl)-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

There total 4 articles about 3'-O-(3-hydroxy-1,1,3,3-tetraisopropyldisiloxan-1-yl)-5'-O-(monomethoxytrityl)-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 173169-22-7
3'-O-(3-hydroxy-1,1,3,3-tetraisopropyldisiloxan-1-yl)-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

: 14470-28-1
mono-4-methoxytrityl chloride

: 173169-28-3
3'-O-(3-hydroxy-1,1,3,3-tetraisopropyldisiloxan-1-yl)-5'-O-(monomethoxytrityl)-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

Guidance literature:: With pyridine; for 15h; Ambient temperature;
DOI:10.1002/hlca.19950780706

Reference yield:

: 20264-95-3
2-(4-nitrophenyl)ethyl chloride

: 173169-28-3
3'-O-(3-hydroxy-1,1,3,3-tetraisopropyldisiloxan-1-yl)-5'-O-(monomethoxytrityl)-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Na₂S₂O₃*5H₂O, 2.) ice, AcOH, Cl₂ gas / 1.) MeOH/water, 7-8 h, reflux, 2.) MeOH, water, 30 min

2: 75 percent / pyridine / 1 h / Ambient temperature

3: 69 percent / 1 N HCl / dioxane / 0.75 h / Ambient temperature

4: 75 percent / pyridine / 15 h / Ambient temperature

With pyridine; hydrogenchloride; Methamphetamin; chlorine; sodium thiosulfate; acetic acid; In 1,4-dioxane;
DOI:10.1002/hlca.19950780706

Reference yield:

: 80259-15-0
2-(4-nitro-phenyl)ethanesulfonyl chloride

: 173169-28-3
3'-O-(3-hydroxy-1,1,3,3-tetraisopropyldisiloxan-1-yl)-5'-O-(monomethoxytrityl)-2'-O-<2-(4-nitrophenyl)ethylsulfonyl>uridine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / pyridine / 1 h / Ambient temperature

2: 69 percent / 1 N HCl / dioxane / 0.75 h / Ambient temperature

3: 75 percent / pyridine / 15 h / Ambient temperature

With pyridine; hydrogenchloride; In 1,4-dioxane;
DOI:10.1002/hlca.19950780706