(R)-α-methyl-α-<<<2-(trimethylsilyl)ethoxy>methoxy>methyl>-1-(cyanomethyl)-2(S)-pyrrolidine(benzyloxy)methane

Base Information

Chemical Name:(R)-α-methyl-α-<<<2-(trimethylsilyl)ethoxy>methoxy>methyl>-1-(cyanomethyl)-2(S)-pyrrolidine(benzyloxy)methane
CAS No.:123190-90-9
Molecular Formula:C₂₂H₃₆N₂O₃Si
Molecular Weight:404.625
Hs Code.:

Synonyms:(R)-α-methyl-α-<<<2-(trimethylsilyl)ethoxy>methoxy>methyl>-1-(cyanomethyl)-2(S)-pyrrolidine(benzyloxy)methane

Suppliers and Price of (R)-α-methyl-α-<<<2-(trimethylsilyl)ethoxy>methoxy>methyl>-1-(cyanomethyl)-2(S)-pyrrolidine(benzyloxy)methane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-α-methyl-α-<<<2-(trimethylsilyl)ethoxy>methoxy>methyl>-1-(cyanomethyl)-2(S)-pyrrolidine(benzyloxy)methane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-α-methyl-α-<<<2-(trimethylsilyl)ethoxy>methoxy>methyl>-1-(cyanomethyl)-2(S)-pyrrolidine(benzyloxy)methane

There total 8 articles about (R)-α-methyl-α-<<<2-(trimethylsilyl)ethoxy>methoxy>methyl>-1-(cyanomethyl)-2(S)-pyrrolidine(benzyloxy)methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 100-39-0
benzyl bromide

: 123190-89-6
(R)-α-methyl-α-<<<2-(trimethylsilyl)ethoxy>methoxy>methyl>-1-(cyanomethyl)-2(S)-pyrrolidinemethanol

: 123190-90-9
(R)-α-methyl-α-<<<2-(trimethylsilyl)ethoxy>methoxy>methyl>-1-(cyanomethyl)-2(S)-pyrrolidine(benzyloxy)methane

Guidance literature:: With potassium hydride; In tetrahydrofuran; for 0.5h; Heating;
DOI:10.1021/ja961640y

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 123190-90-9
(R)-α-methyl-α-<<<2-(trimethylsilyl)ethoxy>methoxy>methyl>-1-(cyanomethyl)-2(S)-pyrrolidine(benzyloxy)methane

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / i-Pr₂NEt / CH₂Cl₂ / 14 h / Ambient temperature

2: aq. KOH / ethanol / 16 h / 80 °C

3: Et₃N / tetrahydrofuran / 2 h / Ambient temperature

4: 91 percent / KH / tetrahydrofuran / 0.5 h / Heating

With potassium hydroxide; potassium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja961640y

Reference yield:

: 123190-86-3
(1R,7aS)-tetrahydro-1-methyl-1-(hydroxymethyl)-1H,3H-pyrrolo<1,2-c>oxazol-3-one

: 123190-90-9
(R)-α-methyl-α-<<<2-(trimethylsilyl)ethoxy>methoxy>methyl>-1-(cyanomethyl)-2(S)-pyrrolidine(benzyloxy)methane

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / i-Pr₂NEt / CH₂Cl₂ / 14 h / Ambient temperature

2: aq. KOH / ethanol / 16 h / 80 °C

3: Et₃N / tetrahydrofuran / 2 h / Ambient temperature

4: 91 percent / KH / tetrahydrofuran / 0.5 h / Heating

With potassium hydroxide; potassium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ja961640y