2,2,2-trifluoro-N-(4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)-3-((4-methyloxazol-2-yl)methyl)phenyl)acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-(4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)-3-((4-methyloxazol-2-yl)methyl)phenyl)acetamide
CAS No.:1308255-50-6
Molecular Formula:C₂₀H₁₇BF₃N₃O₆S
Molecular Weight:495.244
Hs Code.:

Synonyms:2,2,2-trifluoro-N-(4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)-3-((4-methyloxazol-2-yl)methyl)phenyl)acetamide

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Chemical Property of 2,2,2-trifluoro-N-(4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)-3-((4-methyloxazol-2-yl)methyl)phenyl)acetamide

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Technology Process of 2,2,2-trifluoro-N-(4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)-3-((4-methyloxazol-2-yl)methyl)phenyl)acetamide

There total 7 articles about 2,2,2-trifluoro-N-(4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)-3-((4-methyloxazol-2-yl)methyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1308256-54-3
2-((4-methyloxazol-2-yl)methyl)-4-(2,2,2-trifluoroacetamido)benzene-1-sulfonyl chloride

: 117098-94-9
(5-amino-2-hydroxymethylphenyl)boronic acid

: 1308255-50-6
2,2,2-trifluoro-N-(4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)-3-((4-methyloxazol-2-yl)methyl)phenyl)acetamide

Guidance literature:: With pyridine; In acetonitrile; at 20 ℃; for 3h;

Reference yield:

: 1877-73-2
3-nitro-benzeneacetic acid

: 1308255-50-6
2,2,2-trifluoro-N-(4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)-3-((4-methyloxazol-2-yl)methyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h

2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

3: methanesulfonic acid; phosphorus pentoxide / 96 h / 100 °C / Neat (no solvent)

4: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

5: triethylamine / dichloromethane / 3 h / 20 °C

6: chlorosulfonic acid / 3 h / 0 - 20 °C / Neat (no solvent)

7: pyridine / acetonitrile / 3 h / 20 °C

With pyridine; chlorosulfonic acid; methanesulfonic acid; phosphorus pentoxide; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1308256-51-0
2-(3-nitrophenyl)-N-(1-oxopropan-2-yl)acetamide

: 1308255-50-6
2,2,2-trifluoro-N-(4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)-3-((4-methyloxazol-2-yl)methyl)phenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: methanesulfonic acid; phosphorus pentoxide / 96 h / 100 °C / Neat (no solvent)

2: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3: triethylamine / dichloromethane / 3 h / 20 °C

4: chlorosulfonic acid / 3 h / 0 - 20 °C / Neat (no solvent)

5: pyridine / acetonitrile / 3 h / 20 °C

With pyridine; chlorosulfonic acid; methanesulfonic acid; phosphorus pentoxide; hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; acetonitrile;