4-amino-N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-2-((4-methyloxazol-2-yl)methyl)benzenesulfonamide

Base Information

• Chemical Name: 4-amino-N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-2-((4-methyloxazol-2-yl)methyl)benzenesulfonamide
• CAS No.: 1308255-51-7
• Molecular Formula: C₁₈H₁₈BN₃O₅S
• Molecular Weight: 399.235
• Mol file: 1308255-51-7.mol

Synonyms:4-amino-N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-2-((4-methyloxazol-2-yl)methyl)benzenesulfonamide

Chemical Property of 4-amino-N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-2-((4-methyloxazol-2-yl)methyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-2-((4-methyloxazol-2-yl)methyl)benzenesulfonamide

There total 8 articles about 4-amino-N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-2-((4-methyloxazol-2-yl)methyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,2-trifluoro-N-(4-(N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)sulfamoyl)-3-((4-methyloxazol-2-yl)methyl)phenyl)acetamide (1308255-50-6) → 4-amino-N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-2-((4-methyloxazol-2-yl)methyl)benzenesulfonamide (1308255-51-7)

Guidance literature:

With ammonia; In methanol; at 50 ℃; for 4h; Sealed tube;

Reference yield:

3-nitro-benzeneacetic acid (1877-73-2) → 4-amino-N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-2-((4-methyloxazol-2-yl)methyl)benzenesulfonamide (1308255-51-7)

Guidance literature:

Multi-step reaction with 8 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h

2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C

3: methanesulfonic acid; phosphorus pentoxide / 96 h / 100 °C / Neat (no solvent)

4: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

5: triethylamine / dichloromethane / 3 h / 20 °C

6: chlorosulfonic acid / 3 h / 0 - 20 °C / Neat (no solvent)

7: pyridine / acetonitrile / 3 h / 20 °C

8: ammonia / methanol / 4 h / 50 °C / Sealed tube

With pyridine; chlorosulfonic acid; methanesulfonic acid; phosphorus pentoxide; ammonia; hydrogen; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

2-(3-nitrophenyl)-N-(1-oxopropan-2-yl)acetamide (1308256-51-0) → 4-amino-N-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)-2-((4-methyloxazol-2-yl)methyl)benzenesulfonamide (1308255-51-7)

Guidance literature:

Multi-step reaction with 6 steps

1: methanesulfonic acid; phosphorus pentoxide / 96 h / 100 °C / Neat (no solvent)

2: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C

3: triethylamine / dichloromethane / 3 h / 20 °C

4: chlorosulfonic acid / 3 h / 0 - 20 °C / Neat (no solvent)

5: pyridine / acetonitrile / 3 h / 20 °C

6: ammonia / methanol / 4 h / 50 °C / Sealed tube

With pyridine; chlorosulfonic acid; methanesulfonic acid; phosphorus pentoxide; ammonia; hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane; acetonitrile;

upstream raw materials:

3-nitro-benzeneacetic acid

N-(1-hydroxypropan-2-yl)-2-(3-nitrophenyl)acetamide

2-(3-nitrophenyl)-N-(1-oxopropan-2-yl)acetamide

4-methyl-2-(3-nitrobenzyl)oxazole