N-(5-bromo-2-nitrophenyl)-1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinamine

Base Information

Chemical Name:N-(5-bromo-2-nitrophenyl)-1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinamine
CAS No.:950772-55-1
Molecular Formula:C₂₀H₃₀BrN₃O₃
Molecular Weight:440.38
Hs Code.:

Synonyms:N-(5-bromo-2-nitrophenyl)-1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-bromo-2-nitrophenyl)-1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinamine

Chemical Property:

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Technology Process of N-(5-bromo-2-nitrophenyl)-1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinamine

There total 9 articles about N-(5-bromo-2-nitrophenyl)-1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: trans-1-(4-propoxycyclohexyl)-4-piperidinamine dihydrochloride

: 321-23-3
4-bromo-2-fluoronitrobenzene

: 950772-55-1
N-(5-bromo-2-nitrophenyl)-1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinamine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 - 90 ℃; for 5h;

Reference yield:

: 3612-18-8
N-ethyl-4-piperidone

: 950772-55-1
N-(5-bromo-2-nitrophenyl)-1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinamine

Guidance literature:: Multi-step reaction with 4 steps

1: acetone / 3 h / 0 - 30 °C

2: potassium carbonate / ethanol; water / 1 h / 80 °C / Heating / reflux

3: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 2585.81 Torr

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 - 90 °C

With ammonia; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; ethanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: trans-4-hydroxycyclohexylamine hydrochloride

: 950772-55-1
N-(5-bromo-2-nitrophenyl)-1-[trans-4-(propyloxy)cyclohexyl]-4-piperidinamine

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / water / 3 h / 20 °C

2: 1H-imidazole / N,N-dimethyl-formamide / 3 h / 20 - 40 °C

3: triethylsilane; bismuth(III) bromide / acetonitrile / 0.5 h / 0 - 30 °C

4: hydrazine / ethanol / 2 h / 80 °C

5: potassium carbonate / ethanol; water / 1 h / 80 °C / Heating / reflux

6: ammonia; hydrogen / palladium 10% on activated carbon / methanol / 18 h / 20 °C / 2585.81 Torr

7: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 - 90 °C

With 1H-imidazole; triethylsilane; ammonia; hydrogen; bismuth(III) bromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; hydrazine; palladium 10% on activated carbon; In methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile;