1,2,3,8a-tetrahydro-1-isobutyl-2-tosylcyclohepta[c]pyrrol-6-yl pivalate

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Chemical Name:1,2,3,8a-tetrahydro-1-isobutyl-2-tosylcyclohepta[c]pyrrol-6-yl pivalate
CAS No.:1334209-70-9
Molecular Formula:C₂₅H₃₃NO₄S
Molecular Weight:443.607
Hs Code.:

Synonyms:1,2,3,8a-tetrahydro-1-isobutyl-2-tosylcyclohepta[c]pyrrol-6-yl pivalate

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Chemical Property of 1,2,3,8a-tetrahydro-1-isobutyl-2-tosylcyclohepta[c]pyrrol-6-yl pivalate

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Technology Process of 1,2,3,8a-tetrahydro-1-isobutyl-2-tosylcyclohepta[c]pyrrol-6-yl pivalate

There total 9 articles about 1,2,3,8a-tetrahydro-1-isobutyl-2-tosylcyclohepta[c]pyrrol-6-yl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1334209-55-0
(E)-6-(N-(prop-2-ynyl)-N-tosylamino)-8-methylnon-4-en-1-yn-3-yl pivalate

: 1334209-70-9
1,2,3,8a-tetrahydro-1-isobutyl-2-tosylcyclohepta[c]pyrrol-6-yl pivalate

Guidance literature:: With bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; tris(2,2,2-trifluoroethyl)phosphite; In dichloromethane; at 50 ℃; Inert atmosphere;
DOI:10.1002/anie.201103136

Reference yield:

: 1334209-75-4
C₂₀H₂₇NO₄S

: 1334209-70-9
1,2,3,8a-tetrahydro-1-isobutyl-2-tosylcyclohepta[c]pyrrol-6-yl pivalate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / 3 h / -78 °C / Inert atmosphere

2.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Molecular sieve; Inert atmosphere

3.1: tetrahydrofuran / 20 °C / Inert atmosphere

3.2: Saturated solution

4.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

5.1: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; triethyl phosphite / dichloromethane / 50 °C / Inert atmosphere

With dmap; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; diisobutylaluminium hydride; triethylamine; pyridinium chlorochromate; triethyl phosphite; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja2109097

Reference yield:

: C₁₈H₂₅NO₃S

: 1334209-70-9
1,2,3,8a-tetrahydro-1-isobutyl-2-tosylcyclohepta[c]pyrrol-6-yl pivalate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Molecular sieve; Inert atmosphere

2.1: tetrahydrofuran / 20 °C / Inert atmosphere

2.2: Saturated solution

3.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

4.1: bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; triethyl phosphite / dichloromethane / 50 °C / Inert atmosphere

With dmap; bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; triethylamine; pyridinium chlorochromate; triethyl phosphite; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja2109097