(E)-6-(N-(prop-2-ynyl)-N-tosylamino)-8-methylnon-4-en-1-yn-3-yl pivalate

Base Information

Chemical Name:(E)-6-(N-(prop-2-ynyl)-N-tosylamino)-8-methylnon-4-en-1-yn-3-yl pivalate
CAS No.:1334209-55-0
Molecular Formula:C₂₅H₃₃NO₄S
Molecular Weight:443.607
Hs Code.:

Synonyms:(E)-6-(N-(prop-2-ynyl)-N-tosylamino)-8-methylnon-4-en-1-yn-3-yl pivalate

Suppliers and Price of (E)-6-(N-(prop-2-ynyl)-N-tosylamino)-8-methylnon-4-en-1-yn-3-yl pivalate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-6-(N-(prop-2-ynyl)-N-tosylamino)-8-methylnon-4-en-1-yn-3-yl pivalate

Chemical Property:

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Technology Process of (E)-6-(N-(prop-2-ynyl)-N-tosylamino)-8-methylnon-4-en-1-yn-3-yl pivalate

There total 12 articles about (E)-6-(N-(prop-2-ynyl)-N-tosylamino)-8-methylnon-4-en-1-yn-3-yl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₅NO₃S

: 3282-30-2
pivaloyl chloride

: 1334209-55-0
(E)-6-(N-(prop-2-ynyl)-N-tosylamino)-8-methylnon-4-en-1-yn-3-yl pivalate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1002/anie.201103136

Reference yield:

: 1334209-74-3
C₁₆H₂₁NO₃S

: 1334209-55-0
(E)-6-(N-(prop-2-ynyl)-N-tosylamino)-8-methylnon-4-en-1-yn-3-yl pivalate

Guidance literature:: Multi-step reaction with 5 steps

1: acetonitrile / 20 °C / Inert atmosphere

2: diisobutylaluminium hydride / hexane; dichloromethane / -78 °C / Inert atmosphere

3: pyridinium chlorochromate / dichloromethane / 0 - 20 °C / Inert atmosphere; Molecular sieve

4: tetrahydrofuran / 20 °C / Inert atmosphere

5: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With dmap; diisobutylaluminium hydride; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.1002/anie.201103136

Reference yield:

: 1334209-75-4
C₂₀H₂₇NO₄S

: 1334209-55-0
(E)-6-(N-(prop-2-ynyl)-N-tosylamino)-8-methylnon-4-en-1-yn-3-yl pivalate

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / hexane; dichloromethane / 3 h / -78 °C / Inert atmosphere

2.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Molecular sieve; Inert atmosphere

3.1: tetrahydrofuran / 20 °C / Inert atmosphere

3.2: Saturated solution

4.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

With dmap; diisobutylaluminium hydride; triethylamine; pyridinium chlorochromate; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ja2109097