4-(benzylamino)-2-(2-methoxy-1H-benzo[d]imidazol-1-yl)-6,7-dihydropyrido[3,4-d]pyrimidin-8(5H)-one

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Chemical Name:4-(benzylamino)-2-(2-methoxy-1H-benzo[d]imidazol-1-yl)-6,7-dihydropyrido[3,4-d]pyrimidin-8(5H)-one
CAS No.:1542710-71-3
Molecular Formula:C₂₂H₂₀N₆O₂
Molecular Weight:400.44
Hs Code.:

Synonyms:4-(benzylamino)-2-(2-methoxy-1H-benzo[d]imidazol-1-yl)-6,7-dihydropyrido[3,4-d]pyrimidin-8(5H)-one

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Chemical Property of 4-(benzylamino)-2-(2-methoxy-1H-benzo[d]imidazol-1-yl)-6,7-dihydropyrido[3,4-d]pyrimidin-8(5H)-one

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Technology Process of 4-(benzylamino)-2-(2-methoxy-1H-benzo[d]imidazol-1-yl)-6,7-dihydropyrido[3,4-d]pyrimidin-8(5H)-one

There total 9 articles about 4-(benzylamino)-2-(2-methoxy-1H-benzo[d]imidazol-1-yl)-6,7-dihydropyrido[3,4-d]pyrimidin-8(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1850-14-2
tetramethoxymethane

: 1542711-38-5
C₂₀H₂₀N₆O

: 1542710-71-3
4-(benzylamino)-2-(2-methoxy-1H-benzo[d]imidazol-1-yl)-6,7-dihydropyrido[3,4-d]pyrimidin-8(5H)-one

Guidance literature:: With acetic acid; at 0 - 20 ℃; for 16h;

Reference yield:

: 1000578-08-4
2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

: 1542710-71-3
4-(benzylamino)-2-(2-methoxy-1H-benzo[d]imidazol-1-yl)-6,7-dihydropyrido[3,4-d]pyrimidin-8(5H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 16 h / 0 - 20 °C

2: ruthenium tetroxide; sodium periodate / water; ethyl acetate / 16 h / 0 - 20 °C

3: acetonitrile / 2 h / 0 - 20 °C

4: palladium diacetate; caesium carbonate / 1,4-dioxane / 12 h / 0 - 110 °C

5: hydrogenchloride / ethyl acetate / 1 h / 20 °C

6: acetic acid / 16 h / 0 - 20 °C

With hydrogenchloride; sodium periodate; ruthenium tetroxide; palladium diacetate; caesium carbonate; acetic acid; triethylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate; acetonitrile;

Reference yield:

: 1059735-34-0
7-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

: 1542710-71-3
4-(benzylamino)-2-(2-methoxy-1H-benzo[d]imidazol-1-yl)-6,7-dihydropyrido[3,4-d]pyrimidin-8(5H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: carbonochloridic acid 1-chloro-ethyl ester / 1,2-dichloro-ethane / 16.25 h / 0 - 20 °C

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C

3: ruthenium tetroxide; sodium periodate / water; ethyl acetate / 16 h / 0 - 20 °C

4: acetonitrile / 2 h / 0 - 20 °C

5: palladium diacetate; caesium carbonate / 1,4-dioxane / 12 h / 0 - 110 °C

6: hydrogenchloride / ethyl acetate / 1 h / 20 °C

7: acetic acid / 16 h / 0 - 20 °C

With hydrogenchloride; sodium periodate; ruthenium tetroxide; carbonochloridic acid 1-chloro-ethyl ester; palladium diacetate; caesium carbonate; acetic acid; triethylamine; In 1,4-dioxane; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; acetonitrile;