2-[(4R,5R)-2-(2-Bromo-benzyl)-5-(1-hydroxy-1-methyl-ethyl)-[1,3]dioxolan-4-yl]-propan-2-ol

Base Information

• Chemical Name: 2-[(4R,5R)-2-(2-Bromo-benzyl)-5-(1-hydroxy-1-methyl-ethyl)-[1,3]dioxolan-4-yl]-propan-2-ol
• CAS No.: 207615-42-7
• Molecular Formula: C₁₆H₂₃BrO₄
• Molecular Weight: 359.26
• Mol file: 207615-42-7.mol

Synonyms:2-[(4R,5R)-2-(2-Bromo-benzyl)-5-(1-hydroxy-1-methyl-ethyl)-[1,3]dioxolan-4-yl]-propan-2-ol

Chemical Property of 2-[(4R,5R)-2-(2-Bromo-benzyl)-5-(1-hydroxy-1-methyl-ethyl)-[1,3]dioxolan-4-yl]-propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(4R,5R)-2-(2-Bromo-benzyl)-5-(1-hydroxy-1-methyl-ethyl)-[1,3]dioxolan-4-yl]-propan-2-ol

There total 3 articles about 2-[(4R,5R)-2-(2-Bromo-benzyl)-5-(1-hydroxy-1-methyl-ethyl)-[1,3]dioxolan-4-yl]-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-bromophenyl)acetaldehyde dimethyl acetal (112396-13-1) → 2-[(4R,5R)-2-(2-Bromo-benzyl)-5-(1-hydroxy-1-methyl-ethyl)-[1,3]dioxolan-4-yl]-propan-2-ol (207615-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 63.3 percent / p-toluenesulfonic acid, mol. sieves (4 Angstroem) / toluene / 72 h / Heating

2: 1.) Mg / 1.) Et₂O, reflux, 30 min, 2.) Et₂O, THF, room temp., 2 h

With 4 A molecular sieve; toluene-4-sulfonic acid; magnesium; In toluene;

DOI:10.1002/(SICI)1099-0690(199804)1998:4<711::AID-EJOC711>3.0.CO;2-A

Reference yield:

1-bromo-2-(2-methoxyethenyl)benzene (130089-19-9,130089-23-5,59436-11-2) → 2-[(4R,5R)-2-(2-Bromo-benzyl)-5-(1-hydroxy-1-methyl-ethyl)-[1,3]dioxolan-4-yl]-propan-2-ol (207615-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 82.7 percent / p-toluenesulfonic acid, mol. sieves (4 Angstroem) / toluene / 72 h / Heating

2: 1.) Mg / 1.) Et₂O, reflux, 30 min, 2.) Et₂O, THF, room temp., 2 h

With 4 A molecular sieve; toluene-4-sulfonic acid; magnesium; In toluene;

DOI:10.1002/(SICI)1099-0690(199804)1998:4<711::AID-EJOC711>3.0.CO;2-A

Reference yield:

(4R,5R)-2-(2-Bromo-benzyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester (172794-68-2) + methyl iodide (74-88-4) → 2-[(4R,5R)-2-(2-Bromo-benzyl)-5-(1-hydroxy-1-methyl-ethyl)-[1,3]dioxolan-4-yl]-propan-2-ol (207615-42-7)

Guidance literature:

With magnesium; Yield given. Multistep reaction; 1.) Et₂O, reflux, 30 min, 2.) Et₂O, THF, room temp., 2 h;

DOI:10.1002/(SICI)1099-0690(199804)1998:4<711::AID-EJOC711>3.0.CO;2-A

upstream raw materials:

(4R,5R)-2-(2-Bromo-benzyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester

methyl iodide

2-(2-bromophenyl)acetaldehyde dimethyl acetal

1-bromo-2-(2-methoxyethenyl)benzene

Downstream raw materials:

(4R,5R)-2-(2-Bromo-benzyl)-4,5-bis-(1-methoxy-1-methyl-ethyl)-[1,3]dioxolane