3-[(N-butoxycarbonyl)-N-(2-butoxycarboxamidoethyl)aminopropyl]-1-methyl-4-(1-methyl-4-{1-methyl-4-[p-N,N-bis-(2-chloroethyl)aminobenzamido]pyrrole-2-carboxamido}pyrrole-2-carboxamido)pyrrole-2-carboxamide

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Chemical Name:3-[(N-butoxycarbonyl)-N-(2-butoxycarboxamidoethyl)aminopropyl]-1-methyl-4-(1-methyl-4-{1-methyl-4-[p-N,N-bis-(2-chloroethyl)aminobenzamido]pyrrole-2-carboxamido}pyrrole-2-carboxamido)pyrrole-2-carboxamide
CAS No.:197705-50-3
Molecular Formula:C₄₄H₆₀Cl₂N₁₀O₈
Molecular Weight:927.929
Hs Code.:

3-[(N-butoxycarbonyl)-N-(2-butoxycarboxamidoethyl)aminopropyl]-1-methyl-4-(1-methyl-4-{1-methyl-4-[p-N,N-bis-(2-chloroethyl)aminobenzamido]pyrrole-2-carboxamido}pyrrole-2-carboxamido)pyrrole-2-carboxamide

Synonyms:3-[(N-butoxycarbonyl)-N-(2-butoxycarboxamidoethyl)aminopropyl]-1-methyl-4-(1-methyl-4-{1-methyl-4-[p-N,N-bis-(2-chloroethyl)aminobenzamido]pyrrole-2-carboxamido}pyrrole-2-carboxamido)pyrrole-2-carboxamide

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Chemical Property of 3-[(N-butoxycarbonyl)-N-(2-butoxycarboxamidoethyl)aminopropyl]-1-methyl-4-(1-methyl-4-{1-methyl-4-[p-N,N-bis-(2-chloroethyl)aminobenzamido]pyrrole-2-carboxamido}pyrrole-2-carboxamido)pyrrole-2-carboxamide

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Technology Process of 3-[(N-butoxycarbonyl)-N-(2-butoxycarboxamidoethyl)aminopropyl]-1-methyl-4-(1-methyl-4-{1-methyl-4-[p-N,N-bis-(2-chloroethyl)aminobenzamido]pyrrole-2-carboxamido}pyrrole-2-carboxamido)pyrrole-2-carboxamide

There total 9 articles about 3-[(N-butoxycarbonyl)-N-(2-butoxycarboxamidoethyl)aminopropyl]-1-methyl-4-(1-methyl-4-{1-methyl-4-[p-N,N-bis-(2-chloroethyl)aminobenzamido]pyrrole-2-carboxamido}pyrrole-2-carboxamido)pyrrole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13138-78-8
1-methyl-4-nitro-pyrrol-2-carboxylic acid

: 197705-50-3
3-[(N-butoxycarbonyl)-N-(2-butoxycarboxamidoethyl)aminopropyl]-1-methyl-4-(1-methyl-4-{1-methyl-4-[p-N,N-bis-(2-chloroethyl)aminobenzamido]pyrrole-2-carboxamido}pyrrole-2-carboxamido)pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride / 0.67 h / Heating

2: 75.6 percent / pyridine / CH₂Cl₂ / 3 h / Ambient temperature

3: H₂ / 5percent Pd/C / methanol / 6 h / 760 Torr / Ambient temperature

4: pyridine / CH₂Cl₂ / 3 h / Ambient temperature

5: H₂ / 5percent Pd/C / methanol / 760 Torr / Ambient temperature

6: pyridine / CH₂Cl₂ / 3 h / Ambient temperature

7: H₂ / 5percent Pd/C / methanol / 14 h / 760 Torr / Ambient temperature

8: triethylamine / CH₂Cl₂ / 5 h / Ambient temperature

With pyridine; thionyl chloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0968-0896(97)00096-5

Reference yield:

: 28494-51-1
1-methyl-4-nitro-1H-pyrrole-2-carbonyl chloride

: 197705-50-3
3-[(N-butoxycarbonyl)-N-(2-butoxycarboxamidoethyl)aminopropyl]-1-methyl-4-(1-methyl-4-{1-methyl-4-[p-N,N-bis-(2-chloroethyl)aminobenzamido]pyrrole-2-carboxamido}pyrrole-2-carboxamido)pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 75.6 percent / pyridine / CH₂Cl₂ / 3 h / Ambient temperature

2: H₂ / 5percent Pd/C / methanol / 6 h / 760 Torr / Ambient temperature

3: pyridine / CH₂Cl₂ / 3 h / Ambient temperature

4: H₂ / 5percent Pd/C / methanol / 760 Torr / Ambient temperature

5: pyridine / CH₂Cl₂ / 3 h / Ambient temperature

6: H₂ / 5percent Pd/C / methanol / 14 h / 760 Torr / Ambient temperature

7: triethylamine / CH₂Cl₂ / 5 h / Ambient temperature

With pyridine; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0968-0896(97)00096-5

Reference yield:

: 197705-48-9
(2-tert-Butoxycarbonylamino-ethyl)-{3-[(1-methyl-4-nitro-1H-pyrrole-2-carbonyl)-amino]-propyl}-carbamic acid tert-butyl ester

: 197705-50-3
3-[(N-butoxycarbonyl)-N-(2-butoxycarboxamidoethyl)aminopropyl]-1-methyl-4-(1-methyl-4-{1-methyl-4-[p-N,N-bis-(2-chloroethyl)aminobenzamido]pyrrole-2-carboxamido}pyrrole-2-carboxamido)pyrrole-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / 5percent Pd/C / methanol / 6 h / 760 Torr / Ambient temperature

2: pyridine / CH₂Cl₂ / 3 h / Ambient temperature

3: H₂ / 5percent Pd/C / methanol / 760 Torr / Ambient temperature

4: pyridine / CH₂Cl₂ / 3 h / Ambient temperature

5: H₂ / 5percent Pd/C / methanol / 14 h / 760 Torr / Ambient temperature

6: triethylamine / CH₂Cl₂ / 5 h / Ambient temperature

With pyridine; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1016/S0968-0896(97)00096-5