N-[(1S)-1-(furan-2-yl)propan-1-yl]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[(1S)-1-(furan-2-yl)propan-1-yl]-4-methylbenzenesulfonamide
• CAS No.: 134452-28-1
• Molecular Formula: C₁₄H₁₇NO₃S
• Molecular Weight: 279.36
• Mol file: 134452-28-1.mol

Synonyms:N-[(1S)-1-(furan-2-yl)propan-1-yl]-4-methylbenzenesulfonamide

Chemical Property of N-[(1S)-1-(furan-2-yl)propan-1-yl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1S)-1-(furan-2-yl)propan-1-yl]-4-methylbenzenesulfonamide

There total 7 articles about N-[(1S)-1-(furan-2-yl)propan-1-yl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

(+/-)-4-methyl-N-(1-furan-2-ylpropyl)benzenesulfonamide (134340-63-9) → N-[(1R)-1-(furan-2-yl)propan-1-yl]-4-methylbenzenesulfonamide (134452-33-8) + N-[(1S)-1-(furan-2-yl)propan-1-yl]-4-methylbenzenesulfonamide (134452-28-1) + (S)-2-Ethyl-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one (134340-69-5,148370-19-8,148370-25-6)

Guidance literature:

With titanium(IV) isopropylate; tert.-butylhydroperoxide; calcium hydride; silica gel; D-(-)-diisopropyl tartrate; In dichloromethane; for 72h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1016/0040-4039(91)80360-I

Reference yield: 45.0%

(+/-)-4-methyl-N-(1-furan-2-ylpropyl)benzenesulfonamide (134340-63-9) → N-[(1R)-1-(furan-2-yl)propan-1-yl]-4-methylbenzenesulfonamide (134452-33-8) + N-[(1S)-1-(furan-2-yl)propan-1-yl]-4-methylbenzenesulfonamide (134452-28-1) + (R)-2-Ethyl-6-hydroxy-1-(toluene-4-sulfonyl)-1,6-dihydro-2H-pyridin-3-one (134340-69-5,148370-19-8,148370-25-6)

Guidance literature:

With titanium(IV) isopropylate; tert.-butylhydroperoxide; calcium hydride; L-(+)-diisopropyl tartrate; silica gel; In dichloromethane; for 48h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Ambient temperature;

DOI:10.1016/0040-4039(91)80360-I

Reference yield:

(E)-N-(furan-2-ylmethylene)-4-methylbenzenesulfonamide (135822-87-6) + diethylzinc (557-20-0) → N-[(1R)-1-(furan-2-yl)propan-1-yl]-4-methylbenzenesulfonamide (134452-33-8) + N-[(1S)-1-(furan-2-yl)propan-1-yl]-4-methylbenzenesulfonamide (134452-28-1)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); (S)-1-[2-diphenylphosphinomethyl-4,4-bis(2,4,6-trimethylphenylmethyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one; In toluene; at 0 ℃; for 1h; Title compound not separated from byproducts;

DOI:10.1021/jo035234q

upstream raw materials:

(E)-N-(furan-2-ylmethylene)-4-methylbenzenesulfonamide

ethyllithium

(+/-)-4-methyl-N-(1-furan-2-ylpropyl)benzenesulfonamide

diethylzinc