135822-87-6

Upstream product

• 98-01-1 furfural 
• 70-55-3 toluene-4-sulfonamide 
• 494-47-3 hydrofuramide 
• 98-59-9 p-toluenesulfonyl chloride 
• 4104-47-6 N-sulfinyl-p-toluenesulfonamide 
• 156462-95-2 2-(2-furyl)naphtho<1,8-de>-1,3-dithiin 
• 127-65-1 chloroamine-T 
• 163926-88-3 N-[2-Furan-2-yl-1λ⁴-naphtho[1,8-de][1,3]dithiin-(1E)-ylidene]-4-methyl-benzenesulfonamide 

Downstream Products

• 190272-69-6 2-Furan-2-yl-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid methyl ester 
• 420810-54-4 2-diazo-3-furan-2-yl-3-(toluene-4-sulfonylamino)-propionic acid ethyl ester 
• 501677-21-0 ethyl 2-diazo-3-oxo-5-(N-tosyl)amino-5-(2-furyl)pentanoate 
• 148370-17-6 N-(1-furan-2-yl-but-3-enyl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Direct Mannich-Type Reactions Promoted by Frustrated Lewis Acid/Br?nsted Base Catalysts

Direct Mannich-type reactions that afford both α- and β-amino esters by the reaction of a broad range of carbonyl compounds and aldimines are disclosed. The transformation is promoted by a sterically frustrated Lewis acid/Br?nsted base pair, which is prop

Cyanuric chloride-catalyzed synthesis of N-sulfonyl imines

Cyanuric chloride is an inexpensive, efficient, and mild catalyst for the synthesis of N-sulfonyl imines by the reaction of sulfonamides with aryl aldehydes at 110°C under solvent-free conditions. This method affords the N-sulfonyl imines in short reactio

Triarylmethyl chlorides as novel, efficient, and mild organic catalysts for the synthesis of N-sulfonyl imines under neutral conditions

A highly efficient procedure for the preparation of N-sulfonyl imines via condensation of sulfonamides with aldehydes as well as ketones in the presence of triarylmethyl chlorides as metal-free organo-catalysts at 40 °C is described. The advantages of thi

Screening of chiral phosphines as catalysts for the enantioselective [3+2] annulations of N-tosylimines with allenic esters

The use of chiral, binaphthyl-based phosphepines as catalysts improves previous results for the enantioselective [3+2] cyclisation reactions between allenic esters and N-tosylimines, both in terms of conversion rate and enantioselectivity. Pyrrolines bear

Small-molecule inhibitors of protein geranylgeranyltransferase type I

Small molecules that inhibit the geranylgeranylation of K-Ras4B and RhoA by protein geranylgeranyltransferase type I (GGTase-I) were identified from chemical genetic screens of heterocycles synthesized through phosphine catalysis of allenes. To further improve the efficacy of the GGTase-I inhibitors (GGTIs), 4288 related compounds bearing core dihydropyrrole/pyrrolidine and tetrahydropyridine/piperidine scaffolds were synthesized on SynPhase lanterns in a split-pool manner through phosphine-catalyzed [3 + 2] and [4 + 2] annulations of resin-bound allenoates. Testing of the 4288 analogues resulted in several GGTIs exhibiting submicromolar IC50 values. Because proteins such as Ras and Rho GTPases are implicated in oncogenesis and metastasis, these GGTIs might ultimately lead to the development of novel antitumor therapeutics. Copyright

An efficient and convenient procedure for preparation of N-sulfonylimines catalysed by TiO2/SO42- solid superacid

A facile synthesis of N-sulfonylimines in good to excellent yields was described from aldehydes with sulfonamides catalysed by TiO2/SO 42- solid superacid.

A practical synthesis of N-tosylimines of arylaldehydes

Synthesis of N-tosylimines of arylaldehydes was carried out by the reaction of arylaldehydes and p-toluenesulfonamide in methylene chloride in the presence of trifluoroacetic anhydride as a dehydrating agent.

Imino ene reaction catalyzed by Ytterbium(III) Triflate and TMSCl or TMSOTf

A novel combined system of Yb(OTf)3 with TMSCl or TMSOTf catalyzed an imino ene reaction. The reaction of N-tosylbenzaldimine (1) with α-methylstyrene (2) proceeded smoothly to give homoallylic amine 3 in the presence of a catalytic amount of Y

A new synthetic route to 1,3-oxazolidines via palladium-catalyzed regioselective [ 3 + 2 ] cycloaddition of vinylic oxiranes with imines

Palladium-catalyzed intermolecular reaction of imines (1) with vinylic oxiranes (2) gives the regioselective [3+2] cycloaddition products, 1,3- oxazolidine derivatives (3), in good to excellent yields. The present reaction permits the use of uncoventional

Preparation of N-p-Tosylaldimines by the Intramolecular Photo-Imino Group Migration of Naphthodithiin-1-N-tosylsulfilimines

Naphthodithiin-1-N-tosylsulfilimines (4) were prepared by the reaction of napthodithiins with chloramine-T.Photolysis of 4 undergoes intramolecular imino group rearrangement to give N-tosylaldimines quantitatively together with naphthalene