(1S,4R)-4,7,7-Trimethyl-2-((R)-1,3,4-trimethyl-cyclohex-3-enecarbonyl)-2-aza-bicyclo[2.2.1]heptan-3-one

Base Information

• Chemical Name: (1S,4R)-4,7,7-Trimethyl-2-((R)-1,3,4-trimethyl-cyclohex-3-enecarbonyl)-2-aza-bicyclo[2.2.1]heptan-3-one
• CAS No.: 139278-42-5
• Molecular Formula: C₁₉H₂₉NO₂
• Molecular Weight: 303.445

Synonyms:(1S,4R)-4,7,7-Trimethyl-2-((R)-1,3,4-trimethyl-cyclohex-3-enecarbonyl)-2-aza-bicyclo[2.2.1]heptan-3-one

Chemical Property of (1S,4R)-4,7,7-Trimethyl-2-((R)-1,3,4-trimethyl-cyclohex-3-enecarbonyl)-2-aza-bicyclo[2.2.1]heptan-3-one

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Technology Process of (1S,4R)-4,7,7-Trimethyl-2-((R)-1,3,4-trimethyl-cyclohex-3-enecarbonyl)-2-aza-bicyclo[2.2.1]heptan-3-one

There total 2 articles about (1S,4R)-4,7,7-Trimethyl-2-((R)-1,3,4-trimethyl-cyclohex-3-enecarbonyl)-2-aza-bicyclo[2.2.1]heptan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,4S)-3-Methacryloyl-1,7,7-trimethyl-3-azabicyclo<2.2.1>heptan-2-one (139278-33-4) + 2,3-dimethyl-buta-1,3-diene (513-81-5) → (1S,4R)-4,7,7-Trimethyl-2-((R)-1,3,4-trimethyl-cyclohex-3-enecarbonyl)-2-aza-bicyclo[2.2.1]heptan-3-one (139278-42-5)

Guidance literature:

With methylaluminum dichloride; In dichloromethane; at -78 ℃; Yield given;

DOI:10.1021/ja00032a051

Reference yield:

(1S)-4,7,7-trimethyl-2-azabicyclo<2.2.1>heptan-3-one (24326-88-3,183505-74-0) → (1S,4R)-4,7,7-Trimethyl-2-((R)-1,3,4-trimethyl-cyclohex-3-enecarbonyl)-2-aza-bicyclo[2.2.1]heptan-3-one (139278-42-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran / 0 °C

2: MeAlCl₂ / CH₂Cl₂ / -78 °C

With methylaluminum dichloride; sodium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/ja00032a051

Reference yield:

(1S,4R)-4,7,7-Trimethyl-2-((R)-1,3,4-trimethyl-cyclohex-3-enecarbonyl)-2-aza-bicyclo[2.2.1]heptan-3-one (139278-42-5) → ((R)-1,3,4-Trimethyl-cyclohex-3-enyl)-methanol

Guidance literature:

With lithium aluminium tetrahydride; Yield given;

DOI:10.1021/ja00032a051

upstream raw materials:

(1R,4S)-3-Methacryloyl-1,7,7-trimethyl-3-azabicyclo<2.2.1>heptan-2-one

2,3-dimethyl-buta-1,3-diene

(1S)-4,7,7-trimethyl-2-azabicyclo<2.2.1>heptan-3-one

Downstream raw materials:

(R)-1,3,4-Trimethyl-cyclohex-3-enecarboxylic acid

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