4-hydroxymethyl-3-methoxypyridine-2,5-dicarboxylic acid 5-(4-fluorobenzylamide) 2-hydroxyamide

Base Information

Chemical Name:4-hydroxymethyl-3-methoxypyridine-2,5-dicarboxylic acid 5-(4-fluorobenzylamide) 2-hydroxyamide
CAS No.:1198620-81-3
Molecular Formula:C₁₆H₁₆FN₃O₅
Molecular Weight:349.319
Hs Code.:

Synonyms:4-hydroxymethyl-3-methoxypyridine-2,5-dicarboxylic acid 5-(4-fluorobenzylamide) 2-hydroxyamide

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Chemical Property of 4-hydroxymethyl-3-methoxypyridine-2,5-dicarboxylic acid 5-(4-fluorobenzylamide) 2-hydroxyamide

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Technology Process of 4-hydroxymethyl-3-methoxypyridine-2,5-dicarboxylic acid 5-(4-fluorobenzylamide) 2-hydroxyamide

There total 4 articles about 4-hydroxymethyl-3-methoxypyridine-2,5-dicarboxylic acid 5-(4-fluorobenzylamide) 2-hydroxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1198620-80-2
3-hydroxy-4-hydroxymethyl-pyridine-2,5-dicarboxylic acid 5-cyclohexylmethyl-amide 2-hydroxyamide

: 1198620-81-3
4-hydroxymethyl-3-methoxypyridine-2,5-dicarboxylic acid 5-(4-fluorobenzylamide) 2-hydroxyamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 1h;

Reference yield:

: 1198621-08-7
5-(benzyloxy)-N-(4-fluorobenzyl)-4-(methoxymethyl)-N,6-dimethylnicotinamide

: 1198620-81-3
4-hydroxymethyl-3-methoxypyridine-2,5-dicarboxylic acid 5-(4-fluorobenzylamide) 2-hydroxyamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C

2.1: trifluoroacetic anhydride / dichloromethane / 20 °C

3.1: manganese(IV) oxide / chloroform / 20 °C / Reflux

4.1: sodium cyanide / 1 h / 20 °C

5.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

5.2: 0.5 h / -78 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

7.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h

With sodium cyanide; manganese(IV) oxide; tetrabutyl ammonium fluoride; hydrogen; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; chloroform;

Reference yield:

: 1198621-49-6
C₃₂H₃₅FN₂O₄Si

: 1198620-81-3
4-hydroxymethyl-3-methoxypyridine-2,5-dicarboxylic acid 5-(4-fluorobenzylamide) 2-hydroxyamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: trifluoroacetic anhydride / dichloromethane / 20 °C

2.1: manganese(IV) oxide / chloroform / 20 °C / Reflux

3.1: sodium cyanide / 1 h / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

4.2: 0.5 h / -78 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h

With sodium cyanide; manganese(IV) oxide; tetrabutyl ammonium fluoride; hydrogen; trifluoroacetic anhydride; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; chloroform;