2-(3-methyl-4-nitro-5-isoxazolyl)-1-phenyl-1-ethanol

Base Information

• Chemical Name: 2-(3-methyl-4-nitro-5-isoxazolyl)-1-phenyl-1-ethanol
• CAS No.: 1114993-33-7
• Molecular Formula: C₁₂H₁₂N₂O₄
• Molecular Weight: 248.238
• Mol file: 1114993-33-7.mol

Synonyms:2-(3-methyl-4-nitro-5-isoxazolyl)-1-phenyl-1-ethanol

Chemical Property of 2-(3-methyl-4-nitro-5-isoxazolyl)-1-phenyl-1-ethanol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(3-methyl-4-nitro-5-isoxazolyl)-1-phenyl-1-ethanol

There total 1 articles about 2-(3-methyl-4-nitro-5-isoxazolyl)-1-phenyl-1-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3,5-dimethyl-4-nitroisoxazole (1123-49-5) + benzaldehyde (100-52-7) → 2-(3-methyl-4-nitro-5-isoxazolyl)-1-phenyl-1-ethanol (1114993-33-7)

Guidance literature:

With 1H-imidazole; for 0.0833333h; Milling; Green chemistry;

DOI:10.1016/j.bmcl.2015.01.041

Reference yield: 88.0%

2-(3-methyl-4-nitro-5-isoxazolyl)-1-phenyl-1-ethanol (1114993-33-7) → 2-(3-methyl-4-nitro-5-isoxazolyl)-1-phenyl-1-ethanone

Guidance literature:

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; at 80 ℃; for 6h;

DOI:10.1021/acs.orglett.0c02873

Reference yield:

2-(3-methyl-4-nitro-5-isoxazolyl)-1-phenyl-1-ethanol (1114993-33-7) → benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) + 5-(difluoromethyl)-3-methyl-4-nitroisoxazole

Guidance literature:

Multi-step reaction with 3 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 6 h / 80 °C

2: Selectfluor; potassium phosphate / acetonitrile / 24 h / 20 °C

3: triethylamine / 20 °C

With potassium phosphate; Selectfluor; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate; acetonitrile;

DOI:10.1021/acs.orglett.0c02873

upstream raw materials:

3,5-dimethyl-4-nitroisoxazole

benzaldehyde

Downstream raw materials:

benzoic acid methyl ester