5-fluoro-N₁-(5-nitro-4-thiocyanatopyrimidin-2-yl)benzene-1,2-diamine trifluoroacetate

Base Information

• Chemical Name: 5-fluoro-N₁-(5-nitro-4-thiocyanatopyrimidin-2-yl)benzene-1,2-diamine trifluoroacetate
• CAS No.: 1018978-52-3
• Molecular Formula: C₂HF₃O₂*C₁₁H₇FN₆O₂S
• Molecular Weight: 420.304

Synonyms:5-fluoro-N₁-(5-nitro-4-thiocyanatopyrimidin-2-yl)benzene-1,2-diamine trifluoroacetate

Chemical Property of 5-fluoro-N₁-(5-nitro-4-thiocyanatopyrimidin-2-yl)benzene-1,2-diamine trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-fluoro-N₁-(5-nitro-4-thiocyanatopyrimidin-2-yl)benzene-1,2-diamine trifluoroacetate

There total 5 articles about 5-fluoro-N₁-(5-nitro-4-thiocyanatopyrimidin-2-yl)benzene-1,2-diamine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-fluoro-2-(5-nitro-4-thiocyanatopyrimidin-2-ylamino)phenylcarbamate (911826-14-7) → 5-fluoro-N1-(5-nitro-4-thiocyanatopyrimidin-2-yl)benzene-1,2-diamine trifluoroacetate (1018978-52-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 1.5h;

Reference yield:

2-nitro-4-fluoroaniline (364-78-3) → 5-fluoro-N1-(5-nitro-4-thiocyanatopyrimidin-2-yl)benzene-1,2-diamine trifluoroacetate (1018978-52-3)

Guidance literature:

Multi-step reaction with 4 steps

1: dmap / dichloromethane / 15 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h

3: potassium carbonate / acetonitrile / 15 h

4: trifluoroacetic acid / dichloromethane / 1.5 h

With potassium carbonate; trifluoroacetic acid; dmap; In dichloromethane; acetonitrile;

Reference yield:

tert-butyl-N-((tert-butoxy)carbonyl)-N-(4-fluoro-2-nitrophenyl)carbamate → 5-fluoro-N1-(5-nitro-4-thiocyanatopyrimidin-2-yl)benzene-1,2-diamine trifluoroacetate (1018978-52-3)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h

2: potassium carbonate / acetonitrile / 15 h

3: trifluoroacetic acid / dichloromethane / 1.5 h

With potassium carbonate; trifluoroacetic acid; In dichloromethane; acetonitrile;

upstream raw materials:

tert-butyl 4-fluoro-2-(5-nitro-4-thiocyanatopyrimidin-2-ylamino)phenylcarbamate

(4-fluoro-2-nitrophenyl)carbamic acid tert-butyl ester

2-chloro-5-nitro-4-thiocyanatopyrimidine

2-nitro-4-fluoroaniline

Downstream raw materials:

N₄-((1R,4R)-4-(tert-Butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)pyrimidine-4,5-diamine

N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-amine

9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7H-purin-8(9H)-one

9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7-methyl-7H-purin-8(9H)-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1018978-52-3 5-fluoro-N₁-(5-nitro-4-thiocyanatopyrimidin-2-yl)benzene-1,2-diamine trifluoroacetate

Send

Send

Metric Ton KG G Pound L ML

Send

Send