9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7-methyl-7H-purin-8(9H)-one

Base Information

Chemical Name:9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7-methyl-7H-purin-8(9H)-one
CAS No.:1141855-84-6
Molecular Formula:C₃₉H₃₇FN₆O₂Si
Molecular Weight:668.846
Hs Code.:

Synonyms:9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7-methyl-7H-purin-8(9H)-one

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Chemical Property of 9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7-methyl-7H-purin-8(9H)-one

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Technology Process of 9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7-methyl-7H-purin-8(9H)-one

There total 15 articles about 9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7-methyl-7H-purin-8(9H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1141855-83-5
9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7H-purin-8(9H)-one

: 74-88-4
methyl iodide

: 1141855-84-6
9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7-methyl-7H-purin-8(9H)-one

Guidance literature:: With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine bound on polystyrene; In acetonitrile; at 20 ℃; for 15h; Polystyrene

Reference yield:

: 1019207-94-3
(R)-2,2,2-trifluoro-N-(1,2,3,4-tetrahydronaphthalen-1-yl)acetamide

: 1141855-84-6
9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7-methyl-7H-purin-8(9H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: magnesium sulfate / water; acetone / 0.08 h / 0 °C

1.2: 0 - 20 °C

2.1: formic acid; triethylamine / Noyori's catalyst / N,N-dimethyl-formamide / 50 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

4.1: potassium carbonate / methanol; water / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

6.1: hydrogen / nickel / tetrahydrofuran; water / 15 h / 20 °C

7.1: tetrahydrofuran / 15 h

8.1: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine bound on polystyrene / acetonitrile / 15 h / 20 °C

With 1H-imidazole; formic acid; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine bound on polystyrene; hydrogen; magnesium sulfate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; Noyori's catalyst; nickel; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 579474-17-2
(4-fluoro-2-nitrophenyl)carbamic acid tert-butyl ester

: 1141855-84-6
9-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-7-methyl-7H-purin-8(9H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / acetonitrile / 15 h

2: trifluoroacetic acid / dichloromethane / 1.5 h

3: methanol / 16 h

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0 - 20 °C

5: hydrogen / nickel / tetrahydrofuran; water / 15 h / 20 °C

6: tetrahydrofuran / 15 h

7: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine bound on polystyrene / acetonitrile / 15 h / 20 °C

With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine bound on polystyrene; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; nickel; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;