3-(benzyloxy)-N-methyl-N-(6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexyl)aniline

Base Information

Chemical Name:3-(benzyloxy)-N-methyl-N-(6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexyl)aniline
CAS No.:1610998-82-7
Molecular Formula:C₃₁H₃₈F₃N₃O
Molecular Weight:525.657
Hs Code.:

Synonyms:3-(benzyloxy)-N-methyl-N-(6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexyl)aniline

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Chemical Property of 3-(benzyloxy)-N-methyl-N-(6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexyl)aniline

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Technology Process of 3-(benzyloxy)-N-methyl-N-(6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexyl)aniline

There total 4 articles about 3-(benzyloxy)-N-methyl-N-(6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexyl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1610998-71-4
N-[3-(benzyloxy)phenyl]-N-methyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexanamide

: 1610998-82-7
3-(benzyloxy)-N-methyl-N-(6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexyl)aniline

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Cooling with ice; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2014.04.034

Reference yield:

: 1610998-50-9
N-[3-(benzyloxy)phenyl]-6-bromo-N-methylhexanamide

: 1610998-82-7
3-(benzyloxy)-N-methyl-N-(6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexyl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Cooling with ice; Inert atmosphere; Reflux

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.04.034

Reference yield:

: 22809-37-6
6-bromohexanoyl chloride

: 1610998-82-7
3-(benzyloxy)-N-methyl-N-(6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexyl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / ethyl acetate; water / 0.33 h / 20 °C / Cooling with ice

2: triethylamine / N,N-dimethyl-formamide / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Cooling with ice; Inert atmosphere; Reflux

With lithium aluminium tetrahydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.04.034