N-[3-(benzyloxy)phenyl]-N-methyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexanamide

Base Information

Chemical Name:N-[3-(benzyloxy)phenyl]-N-methyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexanamide
CAS No.:1610998-71-4
Molecular Formula:C₃₁H₃₆F₃N₃O₂
Molecular Weight:539.641
Hs Code.:

Synonyms:N-[3-(benzyloxy)phenyl]-N-methyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3-(benzyloxy)phenyl]-N-methyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexanamide

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Technology Process of N-[3-(benzyloxy)phenyl]-N-methyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexanamide

There total 3 articles about N-[3-(benzyloxy)phenyl]-N-methyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1610998-50-9
N-[3-(benzyloxy)phenyl]-6-bromo-N-methylhexanamide

: 15532-75-9
1-(3-Trifluoromethylphenyl)piperazine

: 1610998-71-4
N-[3-(benzyloxy)phenyl]-N-methyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexanamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.ejmech.2014.04.034

Reference yield:

: 22809-37-6
6-bromohexanoyl chloride

: 1610998-71-4
N-[3-(benzyloxy)phenyl]-N-methyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexanamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / ethyl acetate; water / 0.33 h / 20 °C / Cooling with ice

2: triethylamine / N,N-dimethyl-formamide / 20 °C

With sodium hydrogencarbonate; triethylamine; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.04.034

Reference yield:

: 33905-38-3
3-(benzyloxy)-N-methylaniline

: 1610998-71-4
N-[3-(benzyloxy)phenyl]-N-methyl-6-{4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}hexanamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / ethyl acetate; water / 0.33 h / 20 °C / Cooling with ice

2: triethylamine / N,N-dimethyl-formamide / 20 °C

With sodium hydrogencarbonate; triethylamine; In water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.04.034