(+/-)-2-((Z)-5-(4-hydroxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

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Chemical Name:(+/-)-2-((Z)-5-(4-hydroxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid
CAS No.:1414727-23-3
Molecular Formula:C₁₉H₁₅NO₄S₂
Molecular Weight:385.464
Hs Code.:

Synonyms:(+/-)-2-((Z)-5-(4-hydroxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

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Chemical Property of (+/-)-2-((Z)-5-(4-hydroxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

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Technology Process of (+/-)-2-((Z)-5-(4-hydroxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

There total 2 articles about (+/-)-2-((Z)-5-(4-hydroxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 24834-68-2
2-(4-oxo-2-thioxo-1,3-thiazolidin-3-yl)-3-phenylpropanoic acid

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1414727-23-3
(+/-)-2-((Z)-5-(4-hydroxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

Guidance literature:: With 1-methyl-piperazine; ammonium acetate; In toluene; at 110 ℃; for 15h; Molecular sieve;
DOI:10.1016/j.bioorg.2012.08.002

Reference yield:

: C₁₀H₁₁NO₂S₂*2H₃N

: 1414727-23-3
(+/-)-2-((Z)-5-(4-hydroxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 0.5 h

1.2: 1 h / 5 - 10 °C

1.3: 3 h / 60 - 70 °C

2.1: 1-methyl-piperazine; ammonium acetate / toluene / 15 h / 110 °C / Molecular sieve

With 1-methyl-piperazine; ammonium acetate; sodium hydroxide; In water; toluene; 2.1: |Knoevenagel Condensation;
DOI:10.1016/j.bioorg.2012.08.002