24834-68-2

Upstream product

• 150-30-1 Phenylalanine 
• 79-11-8 chloroacetic acid 
• 3926-62-3 sodium monochloroacetic acid 

Downstream Products

• 1414727-15-3 (+/-)-2-((Z)-5-(4-chlorobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid 
• 24834-75-1 (+/-)-2-((Z)-5-(4-(dimethylamino)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid 
• 1414727-23-3 (+/-)-2-((Z)-5-(4-hydroxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid 
• 928339-97-3 (+/-)-2-((Z)-5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid 
• 1414727-25-5 (+/-)-2-((Z)-5-(4-methoxybenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid 
• 1414727-27-7 (+/-)-2-((Z)-5-((furan-2-yl)methylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid 
• 24834-73-9 2-{5-[1-(2-Hydroxy-phenyl)-meth-(Z)-ylidene]-4-oxo-2-thioxo-thiazolidin-3-yl}-3-phenyl-propionic acid 
• 1261158-89-7 C₁₉H₁₃Cl₂NO₃S₂ 

Relevant academic research and scientific papers

Discovery of novel glitazones incorporated with phenylalanine and tyrosine: Synthesis, antidiabetic activity and structure-activity relationships

We report a series of new glitazones incorporated with phenylalanine and tyrosine. All the compounds were tested for their in vitro glucose uptake activity using rat-hemidiaphragm, both in presence and absence of insulin. Six of the most active compounds

Efficient conversion of N-terminal of L-tyrosine, DL-phenyl alanine, and glycine to substituted 2-thioxo-thiazolidine-4-ones: A stereospecific synthesis

We report facile and efficient conversion of the amino functional group of amino acids such a s L-tyrosine, DL-phenylalanine, and glycine to the corresponding (±)-2-thioxo-thiazolidine-4-ones (rhodanines). Stereospecific synthesis of amino acid-incorporated rhodanine is achieved in the case of L-tyrosine. Knoevenagel condensation over the active methylene group at the fifth position of the corresponding rhodanines is also described. The substituted rhodanine incorporated with tyrosine in the form of a dimer connected via two-carbon linker possesses significant anticancer activity against A549 cells (human lung cancer cells).