N-{[(3S,4R,6R)-6-[(benzyloxy)methyl]-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioyl}-2-(9H-fluoren-9-yl)acetamide

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Chemical Name:N-{[(3S,4R,6R)-6-[(benzyloxy)methyl]-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioyl}-2-(9H-fluoren-9-yl)acetamide
CAS No.:1425947-63-2
Molecular Formula:C₃₆H₃₄F₂N₂O₅S
Molecular Weight:644.739
Hs Code.:

Synonyms:N-{[(3S,4R,6R)-6-[(benzyloxy)methyl]-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioyl}-2-(9H-fluoren-9-yl)acetamide

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Chemical Property of N-{[(3S,4R,6R)-6-[(benzyloxy)methyl]-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioyl}-2-(9H-fluoren-9-yl)acetamide

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Technology Process of N-{[(3S,4R,6R)-6-[(benzyloxy)methyl]-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioyl}-2-(9H-fluoren-9-yl)acetamide

There total 9 articles about N-{[(3S,4R,6R)-6-[(benzyloxy)methyl]-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioyl}-2-(9H-fluoren-9-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1425947-63-2
N-{[(3S,4R,6R)-6-[(benzyloxy)methyl]-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioyl}-2-(9H-fluoren-9-yl)acetamide

Guidance literature:: In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1425947-61-0
(3aR,5R,7aS)-5-[(benzyloxy)methyl]-7a-(2,4-difluorophenyl)hexahydro-1H-pyrano[3,4-c][1,2]oxazole

: 1425947-63-2
N-{[(3S,4R,6R)-6-[(benzyloxy)methyl]-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioyl}-2-(9H-fluoren-9-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; zinc / 18 h / 20 °C / Inert atmosphere

2: dichloromethane / 18 h / 20 °C / Inert atmosphere

With acetic acid; zinc; In dichloromethane;
DOI:10.1021/jm501833t

Reference yield:

: 14618-80-5
(R)-benzyl glycidol

: 1425947-63-2
N-{[(3S,4R,6R)-6-[(benzyloxy)methyl]-3-(2,4-difluorophenyl)-4-(hydroxymethyl)tetrahydro-2H-pyran-3-yl]carbamothioyl}-2-(9H-fluoren-9-yl)acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: copper(l) iodide / tetrahydrofuran; diethyl ether / 18 h / -78 - 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 42 h / 0 - 68 °C / Inert atmosphere

3.1: hydrogenchloride / tetrahydrofuran; water / 1 h / 75 °C / Inert atmosphere

4.1: sodium acetate / water; ethanol / 0.25 h / Inert atmosphere

4.2: 18 h / 60 °C / Inert atmosphere

5.1: sodium hypochlorite; triethylamine / dichloromethane / 22 - 25.5 °C / Inert atmosphere

6.1: boron trifluoride diethyl etherate / toluene; di-isopropyl ether / 0.5 h / -78 °C / Inert atmosphere

6.2: 1.33 h / -78 - -73 °C / Inert atmosphere

7.1: acetic acid; zinc / 18 h / 20 °C / Inert atmosphere

8.1: dichloromethane / 18 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium hypochlorite; copper(l) iodide; boron trifluoride diethyl etherate; sodium acetate; sodium hydride; acetic acid; triethylamine; zinc; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; di-isopropyl ether; water; toluene; mineral oil;
DOI:10.1021/jm501833t