(-)-(S)-5-fluoro-3-(3-fluorophenyl)-2-(1-hydroxyethyl)-4H-chromen-4-one

Base Information

Chemical Name:(-)-(S)-5-fluoro-3-(3-fluorophenyl)-2-(1-hydroxyethyl)-4H-chromen-4-one
CAS No.:1408087-82-0
Molecular Formula:C₁₇H₁₂F₂O₃
Molecular Weight:302.277
Hs Code.:

Synonyms:(-)-(S)-5-fluoro-3-(3-fluorophenyl)-2-(1-hydroxyethyl)-4H-chromen-4-one

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Chemical Property of (-)-(S)-5-fluoro-3-(3-fluorophenyl)-2-(1-hydroxyethyl)-4H-chromen-4-one

Chemical Property:

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Technology Process of (-)-(S)-5-fluoro-3-(3-fluorophenyl)-2-(1-hydroxyethyl)-4H-chromen-4-one

There total 10 articles about (-)-(S)-5-fluoro-3-(3-fluorophenyl)-2-(1-hydroxyethyl)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1408087-86-4
2-acetyl-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

: 1408087-82-0
(-)-(S)-5-fluoro-3-(3-fluorophenyl)-2-(1-hydroxyethyl)-4H-chromen-4-one

: 1408087-84-2
(R)-5-fluoro-3-(3-fluorophenyl)-2-(1-hydroxyethyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: S-Alpine borane / tetrahydrofuran / 24 h / 70 °C

2: CHIRALPAK AD-H column / carbon dioxide / Resolution of racemate

With S-Alpine borane; CHIRALPAK AD-H column; In tetrahydrofuran; carbon dioxide;

Reference yield:

: 1408087-80-8
5-fluoro-3-(3-fluorophenyl)-2-(1-hydroxyethyl)-4H-chromen-4-one

: 1408087-82-0
(-)-(S)-5-fluoro-3-(3-fluorophenyl)-2-(1-hydroxyethyl)-4H-chromen-4-one

: 1408087-84-2
(R)-5-fluoro-3-(3-fluorophenyl)-2-(1-hydroxyethyl)-4H-chromen-4-one

Guidance literature:: With CHIRALPAK AD-H column; In carbon dioxide; Resolution of racemate;

Reference yield:

: 93339-98-1
1-(2-fluoro-6-hydroxyphenyl)ethan-1-one

: 1408087-82-0
(-)-(S)-5-fluoro-3-(3-fluorophenyl)-2-(1-hydroxyethyl)-4H-chromen-4-one

: 1408087-84-2
(R)-5-fluoro-3-(3-fluorophenyl)-2-(1-hydroxyethyl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloromethane / 3 h / 45 °C / Cooling with ice

2.1: sodium hydride / dimethyl sulfoxide / 13 h / 0 - 20 °C

2.2: 12 h / Reflux

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 12 h / 20 °C

4.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 12 h / Reflux; Inert atmosphere

5.1: N-Bromosuccinimide / 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 12 h / 80 °C

6.1: butan-1-ol / dimethyl sulfoxide / 3 h / 120 °C

7.1: CHIRALPAK AD-H column / carbon dioxide / Resolution of racemate

With N-Bromosuccinimide; sodium hydride; potassium carbonate; butan-1-ol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,2'-azobis(isobutyronitrile); In 1,4-dioxane; tetrachloromethane; dichloromethane; carbon dioxide; water; dimethyl sulfoxide; N,N-dimethyl-formamide;