1-{2-[(2-bromo-thiazole-4-carbonyl)-amin-phenyl]piperidin-4-yl}-carbamic acid ter-butylester

Base Information

• Chemical Name: 1-{2-[(2-bromo-thiazole-4-carbonyl)-amin-phenyl]piperidin-4-yl}-carbamic acid ter-butylester
• CAS No.: 1023594-68-4
• Molecular Formula: C₂₀H₂₅BrN₄O₃S
• Molecular Weight: 481.413
• Mol file: 1023594-68-4.mol

Synonyms:1-{2-[(2-bromo-thiazole-4-carbonyl)-amin-phenyl]piperidin-4-yl}-carbamic acid ter-butylester

Chemical Property of 1-{2-[(2-bromo-thiazole-4-carbonyl)-amin-phenyl]piperidin-4-yl}-carbamic acid ter-butylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{2-[(2-bromo-thiazole-4-carbonyl)-amin-phenyl]piperidin-4-yl}-carbamic acid ter-butylester

There total 1 articles about 1-{2-[(2-bromo-thiazole-4-carbonyl)-amin-phenyl]piperidin-4-yl}-carbamic acid ter-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

2-bromothiazole-4-carboxylic Acid (5198-88-9) + [1-(2-amino-phenyl)-piperidin-4-yl]-carbamic acid tert-butyl ester (1023594-61-7) → 1-{2-[(2-bromo-thiazole-4-carbonyl)-amin-phenyl]piperidin-4-yl}-carbamic acid ter-butylester (1023594-68-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield:

3-aminothiophene-2-carbonitrile (56489-05-5) + 1-{2-[(2-bromo-thiazole-4-carbonyl)-amin-phenyl]piperidin-4-yl}-carbamic acid ter-butylester (1023594-68-4) → C20H20N6OS2 (1023652-89-2)

Guidance literature:

3-aminothiophene-2-carbonitrile; 1-{2-[(2-bromo-thiazole-4-carbonyl)-amin-phenyl]piperidin-4-yl}-carbamic acid ter-butylester; With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 110 ℃; for 15h;

With trifluoroacetic acid; for 0.166667h;

Reference yield:

4-amino-pyridin-2-ol hydrochloride + 1-{2-[(2-bromo-thiazole-4-carbonyl)-amin-phenyl]piperidin-4-yl}-carbamic acid ter-butylester (1023594-68-4) → C20H22N6O2S (1023653-07-7)

Guidance literature:

4-amino-pyridin-2-ol hydrochloride; 1-{2-[(2-bromo-thiazole-4-carbonyl)-amin-phenyl]piperidin-4-yl}-carbamic acid ter-butylester; With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tert-butyl alcohol; at 100 ℃; for 15h;

With trifluoroacetic acid; for 0.166667h;

upstream raw materials:

2-bromothiazole-4-carboxylic Acid

[1-(2-amino-phenyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Downstream raw materials:

C₂₀H₂₂N₆OS

C₂₀H₂₀N₆OS₂

C₁₉H₂₁N₇O₂S

C₂₀H₂₂N₆O₂S