5198-88-9

Basic information

• Product Name: 2-Bromo-4-thiazolecarboxylic acid
• Synonyms: 2-BROMOTHIAZOLE-4-CARBOXYLIC ACID;2-BROMO-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-BROMO-4-THIAZOLECARBOXYLIC ACID;2-Bromo-1,3-thiazole-4-carboxylic acid 97%;4-Thiazolecarboxylic acid, 2-bromo-;2-Bromo-4-carboxy-1,3-thiazole
• CAS NO: 5198-88-9
• Molecular Formula: C₄H₂BrNO₂S
• Molecular Weight: 208.03
• Product Categories: blocks;Bromides;Carboxes;Thiazoles;Miscellaneous;Carboxylic Acids;Thiazoles, Isothiazoles &Benzothiazoles;Organic acids;API intermediates;ADVANCED CHEMICALS;Heterocycles;Carboxylic Acids;Thiazoles, Isothiazoles & Benzothiazoles;Organohalides;Thiazole
• Mol File: 5198-88-9.mol
• Article Data: 19

Chemical Properties

• Melting Point: 212-214
• Boiling Point: 350 °C at 760 mmHg
• Flash Point: 165.5 °C
• Appearance: /
• Density: 2.062 g/cm³
• Vapor Pressure: 1.69E-05mmHg at 25°C
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.13±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-4-thiazolecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4-thiazolecarboxylic acid(5198-88-9)
• EPA Substance Registry System: 2-Bromo-4-thiazolecarboxylic acid(5198-88-9)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• Hazardous Substances Data: 5198-88-9(Hazardous Substances Data)

Usage

Chemical Properties

Pale yellow crystals

InChI:InChI=1/C4H2BrNO2S/c5-4-6-2(1-9-4)3(7)8/h1H,(H,7,8)/p-1

Upstream product

• 170235-26-4 2-bromo-thiazole-4-carboxylic acid methyl ester 
• 100367-77-9 ethyl 2-bromothiazole-4-carboxylate 
• 83553-47-3 2-iodothiazole-4-carboxylic acid ethyl ester 

Downstream Products

• 1160288-86-7 N-[2-( aminocarbonyl)phenyl]-2-bromo-4-thiazolecarboxamide 
• 848501-94-0 2-bromo-1,3-thiazole-4-carboxamide 
• 1023592-97-3 C₁₇H₂₀BrN₅O₂S 
• 1023594-68-4 1-{2-[(2-bromo-thiazole-4-carbonyl)-amin-phenyl]piperidin-4-yl}-carbamic acid ter-butylester 
• 1023298-53-4 tert-butyl 4-(2-(2-bromothiazole-4-carboxamido)phenyl)piperazine-1-carboxylate 
• 1169698-65-0 1,1-dimethylethyl 4-((2-bromo-1,3-thiazol-4-yl)carbonyl)-1-piperazinecarboxylate 
• 906353-04-6 2-morpholinothiazole-4-carboxylic acid 
• 170235-26-4 2-bromo-thiazole-4-carboxylic acid methyl ester 
• 115299-10-0 2-(2-methoxyphenyl)-4-thiazolecarboxylic acid 
• 936691-31-5 2-bromo-4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1,3-thiazole 
• 888314-10-1 2-bromo-N-methoxy-N-methyl-1,3-thiazole-4-carboxamide 

Relevant articles and documents

From 2,6-dichloronicotinic acid to thiopeptide cores

The scope of 2,6-dichloronicotinic acid as a precursor of thiopeptide polyheterocylic cores has been extensively studied in a cross-coupling-based approach. Differentiation of the two chlorinated positions under SNAr conditions and versatility of the carboxylic acid are key for the preparation of 2,3,6-trisubstituted pyridines with complete regiocontrol. With the present strategy, nine different azole-substituted pyridines were synthesized. Studies towards the selective deprotection of their functionalities resulted in a set of fully orthogonal protecting groups that permits the elongation of all three pyridine substituents. Copyright

INDOLE COMPOUNDS AND THEIR USE

The present disclosure relates to indole compounds and pharmaceutical compositions thereof, and their use in stimulating the immune system of patients in need thereof and in treating cancer.

Utilization of an Active Site Mutant Receptor for the Identification of Potent and Selective Atypical 5-HT2C Receptor Agonists

Agonism of the 5-HT2C receptor represents one of the most well-studied and clinically proven mechanisms for pharmacological weight reduction. Selectivity over the closely related 5-HT2A and 5-HT2B receptors is critical as their activation has been shown to lead to undesirable side effects and major safety concerns. In this communication, we report the development of a new screening paradigm that utilizes an active site mutant D134A (D3.32) 5-HT2C receptor to identify atypical agonist structures. We additionally report the discovery and optimization of a novel class of nonbasic heterocyclic amide agonists of 5-HT2C. SAR investigations around the screening hits provided a diverse set of potent agonists at 5-HT2C with high selectivity over the related 5-HT2A and 5-HT2B receptor subtypes. Further optimization through replacement of the amide with a variety of five- and six-membered heterocycles led to the identification of 6-(1-ethyl-3-(quinolin-8-yl)-1H-pyrazol-5-yl)pyridazin-3-amine (69). Oral administration of 69 to rats reduced food intake in an ad libitum feeding model, which could be completely reversed by a selective 5-HT2C antagonist.