O-benzyl-chloroacetol methyl acetal ((2S, 4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran)

Base Information

• Chemical Name: O-benzyl-chloroacetol methyl acetal ((2S, 4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran)
• CAS No.: 866088-07-5
• Molecular Formula: C₁₄H₁₉ClO₃
• Molecular Weight: 270.756
• Mol file: 866088-07-5.mol

Synonyms:O-benzyl-chloroacetol methyl acetal ((2S, 4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran)

Chemical Property of O-benzyl-chloroacetol methyl acetal ((2S, 4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O-benzyl-chloroacetol methyl acetal ((2S, 4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran)

There total 1 articles about O-benzyl-chloroacetol methyl acetal ((2S, 4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((2S,4R)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran-4-ol) (866088-06-4) + benzyl bromide (100-39-0) → O-benzyl-chloroacetol methyl acetal ((2S, 4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran) (866088-07-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 - 80 ℃; for 2h;

Reference yield: 95.0%

O-benzyl-chloroacetol methyl acetal ((2S, 4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran) (866088-07-5) + tetrabutylammonium acetate (10534-59-5) → C16H22O5 (866088-08-6)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 24h;

Reference yield:

O-benzyl-chloroacetol methyl acetal ((2S, 4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran) (866088-07-5) + potassium cyanide (151-50-8) → 1 (2R, 4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl acetonitrile

Guidance literature:

In dimethyl sulfoxide; at 80 ℃; for 96h;

upstream raw materials:

((2S,4R)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran-4-ol)

benzyl bromide

Downstream raw materials:

C₁₆H₂₂O₅

Refernces

• 1、 -. "PROCESS AND INTERMEDIATE COMPOUNDS USEFUL IN THE PREPARATION OF STATINS, PARTICULARLY ROSUVASTATIN". Page/Page column 7. . Retrieved 2010/02/14.