(1S)-1,4-anhydro-1,2-dideoxy-1-([2,2':5',2''-terthiophen]-5-yl)-3,5-di-O-(p-toluoyl)-D-erythro-pentitol

Base Information

Chemical Name:(1S)-1,4-anhydro-1,2-dideoxy-1-([2,2':5',2''-terthiophen]-5-yl)-3,5-di-O-(p-toluoyl)-D-erythro-pentitol
CAS No.:259801-05-3
Molecular Formula:C₃₃H₂₈O₅S₃
Molecular Weight:600.78
Hs Code.:

Synonyms:(1S)-1,4-anhydro-1,2-dideoxy-1-([2,2':5',2''-terthiophen]-5-yl)-3,5-di-O-(p-toluoyl)-D-erythro-pentitol

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Chemical Property of (1S)-1,4-anhydro-1,2-dideoxy-1-([2,2':5',2''-terthiophen]-5-yl)-3,5-di-O-(p-toluoyl)-D-erythro-pentitol

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Technology Process of (1S)-1,4-anhydro-1,2-dideoxy-1-([2,2':5',2''-terthiophen]-5-yl)-3,5-di-O-(p-toluoyl)-D-erythro-pentitol

There total 3 articles about (1S)-1,4-anhydro-1,2-dideoxy-1-([2,2':5',2''-terthiophen]-5-yl)-3,5-di-O-(p-toluoyl)-D-erythro-pentitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 3601-89-6,4330-21-6,52304-86-6,3056-12-0,141846-57-3
Hoffer's chlorosugar

: 94581-95-0
5-bromo-2,2':5',2''-terthiophene

: 259801-05-3
(1S)-1,4-anhydro-1,2-dideoxy-1-([2,2':5',2''-terthiophen]-5-yl)-3,5-di-O-(p-toluoyl)-D-erythro-pentitol

Guidance literature:: 5-bromo-2,2':5',2''-terthiophene; With magnesium; ethylene dibromide; In tetrahydrofuran; at 50 ℃; for 2h;

With cadmium(II) chloride; In tetrahydrofuran; for 2h; Heating;

Hoffer's chlorosugar; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1002/(SICI)1522-2675(19991215)82:12<2160::AID-HLCA2160>3.0.CO;2-4

Reference yield:

: 3480-11-3
5-bromo(2,2'-bithiophene)

: 259801-05-3
(1S)-1,4-anhydro-1,2-dideoxy-1-([2,2':5',2''-terthiophen]-5-yl)-3,5-di-O-(p-toluoyl)-D-erythro-pentitol

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg / I₂ / tetrahydrofuran / 2 h / Heating

1.2: 39 percent / [PdCl₂(dppf)2] / tetrahydrofuran; CH₂Cl₂ / 16 h / -20 - 20 °C

2.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 2 h / 50 °C

2.2: CdCl₂ / tetrahydrofuran / 2 h / Heating

2.3: 55 percent / tetrahydrofuran / 16 h / 20 °C

With magnesium; ethylene dibromide; iodine; In tetrahydrofuran; 1.1: Grignard reaction / 1.2: Arylation / 2.1: Grignard reaction / 2.2: Metallation / 2.3: Arylation;
DOI:10.1002/(SICI)1522-2675(19991215)82:12<2160::AID-HLCA2160>3.0.CO;2-4

Reference yield:

: 1081-34-1
2,2':5',2''-terthiophene

: 259801-05-3
(1S)-1,4-anhydro-1,2-dideoxy-1-([2,2':5',2''-terthiophen]-5-yl)-3,5-di-O-(p-toluoyl)-D-erythro-pentitol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 92 percent / N-bromosuccinimide / dimethylformamide / 14 h / 20 °C

2.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 2 h / 50 °C

2.2: CdCl₂ / tetrahydrofuran / 2 h / Heating

2.3: 55 percent / tetrahydrofuran / 16 h / 20 °C

With N-Bromosuccinimide; magnesium; ethylene dibromide; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Bromination / 2.1: Grignard reaction / 2.2: Metallation / 2.3: Arylation;
DOI:10.1002/(SICI)1522-2675(19991215)82:12<2160::AID-HLCA2160>3.0.CO;2-4