6-((5-fluoro-4-methylpyridin-2-yl)amino)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-methylnicotinamide

Base Information

Chemical Name:6-((5-fluoro-4-methylpyridin-2-yl)amino)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-methylnicotinamide
CAS No.:1609530-14-4
Molecular Formula:C₂₃H₂₃FN₈O₂
Molecular Weight:462.486
Hs Code.:

Synonyms:6-((5-fluoro-4-methylpyridin-2-yl)amino)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-methylnicotinamide

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Chemical Property of 6-((5-fluoro-4-methylpyridin-2-yl)amino)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-methylnicotinamide

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Technology Process of 6-((5-fluoro-4-methylpyridin-2-yl)amino)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-methylnicotinamide

There total 9 articles about 6-((5-fluoro-4-methylpyridin-2-yl)amino)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-methylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1609531-48-7
6-chloro-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)-phenyl)amino)-N-methyl-nicotinamide

: 301222-66-2
2-amino-5-fluoro-4-methylpyridine

: 1609530-14-4
6-((5-fluoro-4-methylpyridin-2-yl)amino)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-methylnicotinamide

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; caesium carbonate; In 1,4-dioxane; at 90 ℃; for 4h; Molecular sieve; Inert atmosphere;

Reference yield:

: 1609530-95-1
4,6-dichloro-N-methylnicotinamide

: 1609530-14-4
6-((5-fluoro-4-methylpyridin-2-yl)amino)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-methylnicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 20 °C / Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium(0); dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; caesium carbonate / 1,4-dioxane / 1 h / 110 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; caesium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/acs.jmedchem.9b00444

Reference yield:

: 1609531-46-5
6-chloro-4-((2-methoxy-3-(4H-1,2,4-triazol-3-yl)phenyl)amino)-N-methylnicotinamide

: 1609530-14-4
6-((5-fluoro-4-methylpyridin-2-yl)amino)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-methylnicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 0.5 h / 20 - 25 °C

2: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine / 1,4-dioxane / 4 h / 90 °C / Molecular sieve; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; potassium carbonate; caesium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide; acetonitrile;