N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)thio]butoxy}benzamide

Base Information

Chemical Name:N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)thio]butoxy}benzamide
CAS No.:1422361-48-5
Molecular Formula:C₂₁H₂₀Cl₂F₂N₂O₅S
Molecular Weight:521.369
Hs Code.:

Synonyms:N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)thio]butoxy}benzamide

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Chemical Property of N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)thio]butoxy}benzamide

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Technology Process of N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)thio]butoxy}benzamide

There total 7 articles about N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)thio]butoxy}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.83%

: 14032-62-3
2-mercapto-γ-butyrolactone

: 1422361-48-5
N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)thio]butoxy}benzamide

Guidance literature:: With potassium carbonate; In acetonitrile;

Reference yield: 85.1%

: 1422361-79-2
3-(4-bromobutoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

: 14032-62-3
2-mercapto-γ-butyrolactone

: 1422361-48-5
N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)thio]butoxy}benzamide

Guidance literature:: With potassium carbonate; In acetonitrile; for 1.5h; Reflux;

Reference yield:

: 151103-08-1
4-difluoromethoxy-3-hydroxybenzaldehyde

: 1422361-48-5
N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)-3-{4-[(2-oxotetrahydro furan-3-yl)thio]butoxy}benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 4 h / Reflux

2: sodium chlorite; aminosulfonic acid; acetic acid / water / 0.5 h / 10 °C

3: sodium hydride / tetrahydrofuran / 1 h / 10 °C

4: potassium carbonate / acetonitrile / 1.5 h / Reflux

With sodium chlorite; aminosulfonic acid; sodium hydride; potassium carbonate; acetic acid; In tetrahydrofuran; water; acetonitrile;
DOI:10.1016/j.bmcl.2014.07.016