2-amino-5-fluorobenzothiophene

Base Information

• Chemical Name: 2-amino-5-fluorobenzothiophene
• CAS No.: 732223-07-3
• Molecular Formula: C₈H₆FNS
• Molecular Weight: 167.207

Synonyms:2-amino-5-fluorobenzothiophene

Chemical Property of 2-amino-5-fluorobenzothiophene

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

5-Fluorobenzo[b]thiophen-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-5-fluorobenzothiophene

There total 4 articles about 2-amino-5-fluorobenzothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

2-(2-bromo-5-fluorophenyl)acetonitrile (127792-49-8,886761-96-2) → 2-amino-5-fluorobenzothiophene (732223-07-3)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; Sodium thiosulfate pentahydrate; caesium carbonate; In ethylene glycol; N,N-dimethyl-formamide; at 140 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1021/ol502381e

Reference yield:

5-fluorobenzo[b]thiophene (70060-12-7) → 2-amino-5-fluorobenzothiophene (732223-07-3)

Guidance literature:

With piperidine; n-butyllithium; sodium azide; hydrogen sulfide; Yield given. Multistep reaction;

DOI:10.1002/jhet.5570300442

Reference yield:

4-Fluorothiophenol (371-42-6) → 2-amino-5-fluorobenzothiophene (732223-07-3)

Guidance literature:

Multi-step reaction with 3 steps

1: NaOEt / ethanol / 15 h / Heating

2: 95 percent / polyphosphoric acid, chlorobenzene / 24 h / Heating

3: 1.) BuLi, 2.) sodium azide, 3.) H₂S gas, piperidine

With piperidine; n-butyllithium; sodium azide; PPA; hydrogen sulfide; sodium ethanolate; chlorobenzene; In ethanol;

DOI:10.1002/jhet.5570300442

upstream raw materials:

5-fluorobenzo[b]thiophene

4-Fluorothiophenol

(2,2-diethoxyethyl)(4-fluorophenyl)sulfane

2-(2-bromo-5-fluorophenyl)acetonitrile

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