70060-12-7

Basic information

• Product Name: 5-FLUOROBENZO[B]THIOPHENE
• Synonyms: 5-FLUOROBENZO[B]THIOPHENE;5-fiuorobenzo[b]thiophene;5-fluoro-1-benzothiophene;5-Fluorobenzothiophene
• CAS NO: 70060-12-7
• Molecular Formula: C₈H₅FS
• Molecular Weight: 152.19
• Mol File: 70060-12-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 59-61 °C(Press: 2 Torr)
• Appearance: /
• Density: 1.298±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-FLUOROBENZO[B]THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUOROBENZO[B]THIOPHENE(70060-12-7)
• EPA Substance Registry System: 5-FLUOROBENZO[B]THIOPHENE(70060-12-7)

Safety Data

• Hazardous Substances Data: 70060-12-7(Hazardous Substances Data)

Usage

General Description

5-FLUOROBENZO[B]THIOPHENE is a chemical compound with the molecular formula C8H5FS. It is a heterocyclic organic compound containing a benzene ring fused to a thiophene ring with a fluorine substituent at the fifth position. 5-FLUOROBENZO[B]THIOPHENE is used in the synthesis of pharmaceuticals and agrochemicals, and it has potential applications in material science and organic electronics. 5-FLUOROBENZO[B]THIOPHENE is also studied for its biological activity and potential pharmacological properties, making it a subject of interest in medicinal chemistry research. It is important to handle this compound with care, as it may pose health and environmental hazards if not properly managed.

Upstream product

• 154630-32-7 methyl 5-fluorobenzo[b]thiophene-2-carboxylate 
• 371-42-6 4-Fluorothiophenol 
• 2646-90-4 2,5-difluorobenzaldehyde 
• 13771-69-2 ethyl 5-fluorobenzo[b]thiophene-2-carboxylate 
• 70060-13-8 5-fluorobenzo[b]thiophene-2-carboxylic acid 
• 874357-16-1 (4-fluorophenylthio)-acetaldehyde dimethyl acetal 
• 352-33-0 1-Chloro-4-fluorobenzene 
• 153687-44-6 (2,2-diethoxyethyl)(4-fluorophenyl)sulfane 

Downstream Products

• 212078-65-4 1-(5-fluorobenzo[b]thiophen-2-yl)-3-(1-triphenylmethyl-1H-imidazol-4-yl)-propan-1-ol 
• 698366-78-8 (E)-3-(5-fluorobenzo[b]thiophen-2-yl)-2-propen-1-ol 
• 698366-58-4 ethyl (E)-3-(5-fluorobenzo[b]thiophen-2-yl)-2-propenoate 
• 698367-59-8 1-(5-fluorobenzo[b]thiophen-2-yl)-3-(1H-imidazol-4-yl)-propan-1-ol 
• 40740-56-5 5-fluoro-1-benzothiophene-3-carbaldehyde 
• 346589-87-5 (2S)-3-[4-(5-fluorobenzo[b]thiophen-2-yl)piperidinyl]-1-(1H-2-methylindol-4-yl)oxy-2-propanol 
• 346592-34-5 4-(5-fluorobenzo[b]thiophen-2-yl)piperidine 
• 346592-32-3 4-(5-fluorobenzo[b]thiophen-2-yl)-1,2,5,6-tetrahydropyridine 
• 197069-41-3 (1R,2R,3S,5S)-(5Z)-7-(2-((5-fluorobenzo[b]thiophene-3-carbonyl)-amino)-6,6-dimethyl-bicyclo[3.1.1]hept-3-yl)-hept-5-enoic acid methyl ester 

Relevant articles and documents

Enantioselective hydroarylation or hydroalkenylation of benzo[b]thiophene 1,1-dioxides with organoboranes

An efficient protocol for the asymmetric hydroarylation and hydroalkenylation of benzo[b]thiophene 1,1-dioxides with organoboranes has been developed. The combination of a rhodium(I) precatalyst and a chiral diene ligand constitutes the catalytic system, which enables the facile synthesis of 2,3-dihydrobenzo[b]thiophene 1,1-dioxides in good yields with high enantioselectivities. The merging of this asymmetric hydroarylation with the downstream alkylations delivers 2,3-dihydrobenzo[b]thiophene 1,1-dioxides that contain two continuous quaternary stereocenters with high enantioselectivities in a diastereodivergent manner.

C-benzo five-membered heteroaromatic aryl glucoside derivative as well as preparation method and application thereof

The invention discloses a C-benzo five-membered heteroaromatic aryl glucoside derivative shown in the general formula (I) (in the description), a preparation method of the derivative or an intermediate of the derivative, as well as application of the derivative. In the general formula (I), R, R1, R2, R3, R4, X and Y are defined in the description. The C-benzo five-membered heteroaromatic aryl glucoside derivative is novel in structure, has quite strong inhibitory activity on SGLT-2, has high selection ratio for SGLT-1 and SGLT-2, and can be used for preparing drugs for treating and preventing diseases relevant to SGLT-2.

GLUCOSYLCERAMIDE SYNTHASE INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).