(2,2,2-Trichloro-acetyl)-carbamic acid (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

Base Information

Chemical Name:(2,2,2-Trichloro-acetyl)-carbamic acid (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester
CAS No.:851963-21-8
Molecular Formula:C₃₁H₃₂Cl₃NO₈
Molecular Weight:652.956
Hs Code.:

Synonyms:(2,2,2-Trichloro-acetyl)-carbamic acid (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

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Chemical Property of (2,2,2-Trichloro-acetyl)-carbamic acid (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

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Technology Process of (2,2,2-Trichloro-acetyl)-carbamic acid (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

There total 1 articles about (2,2,2-Trichloro-acetyl)-carbamic acid (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53008-65-4,641635-63-4
methyl 2,3,4-tri-O-benzyl-D-glucopyranoside

: 3019-71-4
Trichloroacetyl isocyanate

: 851963-21-8
(2,2,2-Trichloro-acetyl)-carbamic acid (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

Guidance literature:: With 4 A molecular sieve; In dichloromethane; at 20 ℃; for 0.0166667h;
DOI:10.1002/anie.200462422

Reference yield:

: 851963-21-8
(2,2,2-Trichloro-acetyl)-carbamic acid (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

: 53008-65-4,641635-63-4
methyl 2,3,4-tri-O-benzyl-D-glucopyranoside

Guidance literature:: (2,2,2-Trichloro-acetyl)-carbamic acid (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester; With polystyrene-bound [1,3,2]diazaphosphorinane; In dichloromethane; at 20 ℃; for 0.166667h;

With potassium hydroxide; In methanol; at 60 ℃; for 3h;
DOI:10.1002/anie.200462422

Reference yield:

: 851963-21-8
(2,2,2-Trichloro-acetyl)-carbamic acid (2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl ester

: 3,4,5,6-Tetrafluoro-phthalic acid 1-methyl ester 2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: polystyrene-bound [1,3,2]diazaphosphorinane / CH₂Cl₂ / 0.17 h / 20 °C

1.2: KOH / methanol / 3 h / 60 °C

2.1: 4-(dimethylamino)pyridine; pyridine / 18 h / 20 °C

3.1: 21 mg / diethyl ether; methanol / 0.08 h / 0 °C

With pyridine; dmap; polystyrene-bound [1,3,2]diazaphosphorinane; In methanol; diethyl ether; dichloromethane;
DOI:10.1002/anie.200462422