4-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)phenyl)butanamide

Base Information

Chemical Name:4-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)phenyl)butanamide
CAS No.:1606976-79-7
Molecular Formula:C₂₄H₂₄ClN₃O
Molecular Weight:405.927
Hs Code.:

Synonyms:4-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)phenyl)butanamide

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Chemical Property of 4-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)phenyl)butanamide

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Technology Process of 4-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)phenyl)butanamide

There total 5 articles about 4-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)phenyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1606976-40-2
4-chloro-2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine hydrochloride

: 69024-58-4
4-(p-aminophenyl)butyramide

: 1606976-79-7
4-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)phenyl)butanamide

Guidance literature:: With hydrogenchloride; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 2h; Microwave irradiation;

Reference yield:

: 15118-60-2
4-(4-aminophenyl)butyric Acid

: 1606976-79-7
4-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)phenyl)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1: sulfuric acid / 1.5 h / Reflux

2: ammonia; ammonium chloride / methanol / 20 h / 100 °C

3: hydrogenchloride / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C / Microwave irradiation

With hydrogenchloride; sulfuric acid; ammonia; ammonium chloride; In 1-methyl-pyrrolidin-2-one; methanol;

Reference yield:

: 1187830-87-0
2,4-dichloro-6,7-dihydro-5H-cyclopenta[b]pyridine hydrochloric acid salt

: 1606976-79-7
4-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)phenyl)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; ethanol; water / 4 h / 90 °C / Inert atmosphere

2: hydrogenchloride / 1-methyl-pyrrolidin-2-one / 2 h / 120 °C / Microwave irradiation

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1-methyl-pyrrolidin-2-one; ethanol; water; toluene;