[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-yl}-amine

Base Information

Chemical Name:[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-yl}-amine
CAS No.:718619-76-2
Molecular Formula:C₂₂H₂₆F₃IN₄O₂Si
Molecular Weight:590.459
Hs Code.:

Synonyms:[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-yl}-amine

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Chemical Property of [2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-yl}-amine

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Technology Process of [2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-yl}-amine

There total 1 articles about [2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-yl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.4%

: 718619-75-1
4'-(2-(tert-butyl-dimethyl-silanyloxy)-ethylamine)-1'-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)]-semicarbazole

: 718619-76-2
[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-yl}-amine

Guidance literature:: With tetrachloromethane; polystyrene-PPh₃; triethylamine; In dichloromethane; for 2.5h; Heating / reflux;

Reference yield: 66.7%

: 718619-76-2
[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-yl}-amine

: 2-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-ylamino}-ethanol

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 0 - 20 ℃; for 6h;

Reference yield:

: 110-71-4
1,2-dimethoxyethane

: 718619-76-2
[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-yl}-amine

: 718618-98-5
2-(5-{3,4-difluoro-2-[2-fluoro-4-(2-hydroxy-ethyl)phenylamino]-phenyl}-[1,3,4]oxadiazol-2-ylamino)ethanol

Guidance literature:: 1,2-dimethoxyethane; [2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-{5-[3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-phenyl]-[1,3,4]oxadiazol-2-yl}-amine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; for 0.5h;

With 2,4,6-trivinyl-cyclotriboroxane pyridine complex; potassium carbonate; In water; for 1.5h; Heating / reflux;

With sodium perborate; borane-THF; tetrabutyl ammonium fluoride; acetic acid; more than 3 stages;