(2-PHENYL-1,3-OXAZOL-4-YL)ACETONITRILE

Base Information

• Chemical Name: (2-PHENYL-1,3-OXAZOL-4-YL)ACETONITRILE
• CAS No.: 30494-98-5
• Molecular Formula: C11H8 N2 O
• Molecular Weight: 184.197
• Hs Code.: 2934999090
• Mol file: 30494-98-5.mol

Synonyms:(2-PHENYL-1,3-OXAZOL-4-YL)ACETONITRILE

Chemical Property of (2-PHENYL-1,3-OXAZOL-4-YL)ACETONITRILE

Chemical Property:

• PSA: 49.82000
• LogP: 2.40768

Purity/Quality:

99%min ^*data from raw suppliers

(2-PHENYL-1,3-OXAZOL-4-YL)ACETONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-PHENYL-1,3-OXAZOL-4-YL)ACETONITRILE

There total 8 articles about (2-PHENYL-1,3-OXAZOL-4-YL)ACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

sodium cyanide (773837-37-9) + 4-(iodomethyl)-2-phenyloxazole (33162-08-2) → 2-(2-phenyloxazol-4-yl)acetonitrile (30494-98-5)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 50.0%

→ 2-(2-phenyloxazol-4-yl)acetonitrile (30494-98-5)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

2-phenyl-1,3-oxazole-4-carbonyl chloride (1204-70-2) → 2-(2-phenyloxazol-4-yl)acetonitrile (30494-98-5)

Guidance literature:

Multi-step reaction with 3 steps

1: NaBH₄ / dioxane

2: PBr₅ / benzene

3: methanol / Heating

With sodium tetrahydroborate; phosphorus pentabromide; In 1,4-dioxane; methanol; benzene;

DOI:10.1039/jr9610000405

upstream raw materials:

potassium cyanide

4-bromomethyl-2-phenyl-oxazole

2-phenyl-1,3-oxazole-4-carbonyl chloride

2-phenyl-oxazole-4-carboxylic acid ethyl ester

Refernces

• 1、 -. "COMPOUNDS AND METHODS for the inhibition of HDAC". Paragraph 0631-0632; 0680-0681. . Retrieved 2015/11/24.