2-PHENYL-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: 2-PHENYL-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 39819-39-1
• Molecular Formula: C12H11NO3
• Molecular Weight: 217.224
• Hs Code.: 2934999090
• Mol file: 39819-39-1.mol

Synonyms:2-Phenyl-4-oxazolecarboxylicacid ethyl ester;Ethyl 2-phenyl-4-oxazolecarboxylate;

Chemical Property of 2-PHENYL-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• Boiling Point: 340 °C at 760 mmHg
• Flash Point: 159.4 °C
• PSA: 52.33000
• Density: 1.173 g/cm³
• LogP: 2.51830
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-Phenyloxazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PHENYL-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER

There total 37 articles about 2-PHENYL-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethyl 2-chloro-1,3-oxazole-4-carboxylate (460081-18-9) + phenylboronic acid (98-80-6) → 2-phenyl-oxazole-4-carboxylic acid ethyl ester (39819-39-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In toluene; at 90 ℃; for 2.5h;

DOI:10.1016/j.ejmech.2018.10.049

Reference yield: 97.0%

oxazole-4-carboxylic acid ethyl ester (23012-14-8) + bromobenzene (108-86-1,52753-63-6) → 2-phenyl-oxazole-4-carboxylic acid ethyl ester (39819-39-1)

Guidance literature:

With palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; CyJohnPhos; In 1,4-dioxane; at 110 ℃; for 18h; regioselective reaction; Inert atmosphere;

DOI:10.1002/chem.201101615

Reference yield: 92.0%

ethyl 5-(methylthio)-2-phenyloxazole-4-carboxylate (1236209-05-4) → 2-phenyl-oxazole-4-carboxylic acid ethyl ester (39819-39-1)

Guidance literature:

With Raney-Ni (W₂); In ethanol; Reflux;

DOI:10.1021/jo100941f

upstream raw materials:

ethyl 2-diazo-3-oxo-propanoate

benzonitrile

ethyl O-(2'-ethoxycarbonylvinyl)-N-hydroxyiminobenzoate

ethyl N-<(2'-ethoxycarbonylvinyl)oxy>benzimidate

Downstream raw materials:

2-phenyl-1,3-oxazole-4-carboxylic acid

2-phenyl-oxazole-4-carboxylic acid amide

(2-phenyl-1,3-oxazol-4-yl)methanol

5-bromo-2-phenyl-oxazole-4-carboxylic acid ethyl ester